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Direct numerical simulation of stress states in white matter via a triphasic continuum model of 3d axons tethered to glia
Descriptive
TitleInfo
Title
Direct numerical simulation of stress states in white matter via a triphasic continuum model of 3d axons tethered to glia
Name
(type = personal)
NamePart
(type = family)
DeSimone
NamePart
(type = given)
Robert
NamePart
(type = date)
1994-
DisplayForm
Robert DeSimone
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Cuitino
NamePart
(type = given)
Alberto
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Alberto Cuitino
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
Role
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school
TypeOfResource
Text
Genre
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theses
OriginInfo
DateCreated
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2019
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2019-01
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2019
Place
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(type = code)
xx
Language
LanguageTerm
(authority = ISO639-2b);
(type = code)
eng
Abstract
(type = abstract)
Three finite element sub-models were generated with the intent of studying stress propagation in axons under a uniaxial tensile load. The first sub-model used purely non-affine kinematics, where the axons acted independently from the ECM. The second and third sub-models used two different representations of oligodendrocytes to study how stress distributions in the axons are affected by the addition of glial cells. The two sub-models with oligodendrocytes had higher nominal stresses in the system, but lower peak stresses – indicating that the oligodendrocytes do support axons in the extracellular matrix and distribute stresses across the entire system. All three sub-models showed high stresses in regions with high tortuosity and bending stresses between all inflection points in the axon paths. Bending stresses indicate that the system can suffer from fatigue damage if subjected to repeated tensile and/or compressive loading.
Subject
(authority = RUETD)
Topic
Mechanical and Aerospace Engineering
Subject
(authority = ETD-LCSH)
Topic
Axons
Subject
(authority = ETD-LCSH)
Topic
Stress concentration
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_9369
PhysicalDescription
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electronic resource
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (76 pages : illustrations)
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references
Note
(type = statement of responsibility)
by Robert DeSimone
RelatedItem
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-2brh-7v29
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
DeSimone
GivenName
Robert
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(point = start)
2018-11-26 13:05:58
AssociatedEntity
Name
Robert DeSimone
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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1.7
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Microsoft® Word 2016
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2019-01-05T23:51:16
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2019-01-05T23:51:16
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