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Caulobacter crescentus adapts to phosphate starvation by synthesizing anionic glycoglycerolipids and a novel glycosphingolipid

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TypeOfResource
Text
TitleInfo
Title
Caulobacter crescentus adapts to phosphate starvation by synthesizing anionic glycoglycerolipids and a novel glycosphingolipid
Name (type = personal)
NamePart (type = family)
Stankeviciute
NamePart (type = given)
Gabriele
Affiliation
Center for Computational and Integrative Biology (CCIB), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Guan
NamePart (type = given)
Ziqiang
Affiliation
Duke University Medical Center
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Goldfine
NamePart (type = given)
Howard
Affiliation
University of Pennsylvania
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-3941-6233)
NamePart (type = family)
Klein
NamePart (type = given)
Eric A.
Affiliation
Biology, Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Biology
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Camden College of Arts and Sciences
Name (authority = RutgersOrg-Department); (type = corporate)
NamePart
Center for Computational and Integrative Biology (CCIB)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Version of Record (VoR)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
PhysicalDescription
InternetMediaType
application/pdf
Extent
1 online resource (13 pages) : illustrations
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
Caulobacter crescentus adapts to phosphate starvation by elongating its cell body and a polar stalk structure. The stalk is an extension of the Gram-negative envelope containing inner and outer membranes as well as a peptidoglycan cell wall. Cellular elongation requires a 6- to 7-fold increase in membrane synthesis, yet phosphate limitation would preclude the incorporation of additional phospholipids. In the place of phospholipids, C. crescentus can synthesize several glycolipid species, including a novel glycosphingolipid (GSL-2). While glycosphingolipids are ubiquitous in eukaryotes, the presence of GSL-2 in C. crescentus is surprising since GSLs had previously been found only in Sphingomonas species, in which they play a role in outer membrane integrity. In this paper, we identify three proteins required for GSL-2 synthesis: CcbF catalyzes the first step in ceramide synthesis, while Sgt1 and Sgt2 sequentially glycosylate ceramides to produce GSL-2. Unlike in Sphingomonas, GSLs are nonessential in C. crescentus; however, the presence of ceramides does contribute to phage resistance and susceptibility to the cationic antimicrobial peptide polymyxin B. The identification of a novel lipid species specifically produced upon phosphate starvation suggests that bacteria may be able to synthesize a wider variety of lipids in response to stresses than previously observed. Uncovering these lipids and their functional relevance will provide greater insight into microbial physiology and environmental adaptation.
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf); (qualifier = exact)
2019-04-02
AssociatedObject
Type
Journal
Relationship
Has part
Name
mBio
Reference (type = url)
https://doi.org/10.1128/mBio.00107-19
RelatedItem (type = host)
TitleInfo
Title
Klein, Eric A.
Identifier (type = local)
rucore30196400001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-ymz1-7758
Genre (authority = ExL-Esploro)
Journal Article
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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
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I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
RightsDeclaration (AUTHORITY = Creative Commons); (TYPE = Attribution (CC BY)); (ID = https://creativecommons.org/licenses/by/4.0/)
This work has been licensed by the rightsholder under a Creative Commons Attribution (CC BY) 4.0 International License (https://creativecommons.org/licenses/by/4.0/).
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Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
Document
CreatingApplication
Version
1.4
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-03-22T17:29:01
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-06-12T07:15:59
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Adobe LiveCycle PDF Generator
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