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Race as a fundamental cause of disparities in the consequences of infection in children with leukemia

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TitleInfo
Title
Race as a fundamental cause of disparities in the consequences of infection in children with leukemia
Name (type = personal)
NamePart (type = family)
Savage
NamePart (type = given)
Beth
NamePart (type = date)
1967-
DisplayForm
Beth Savage
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Thomas-Hawkins
NamePart (type = given)
Charlotte
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Charlotte Thomas-Hawkins
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Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Flynn
NamePart (type = given)
Linda
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Linda Flynn
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
de Cordova
NamePart (type = given)
Pamela
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Pamela de Cordova
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Cole
NamePart (type = given)
Peter
DisplayForm
Peter Cole
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = personal)
NamePart (type = family)
Stapleton
NamePart (type = given)
Jerod
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Jerod Stapleton
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
DateOther (qualifier = exact); (type = degree)
2019-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2019
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract
Despite gains in overall survival following the diagnosis of leukemia, disparities persist between children belonging to White and non-White racial groups. Infectious complications are the second leading cause of death after the leukemia itself, yet few studies have sought to determine if there are racial differences in these complications that can explain some of the disparities that exist. The purpose of this study was to investigate race as a risk factor for infectious complications in hospitalized children, and when infection is present, if there are racial differences in the progression to severe sepsis and utilization of healthcare resources.

This was a secondary analysis of cross-sectional data compiled from the 2016 Healthcare Cost and Utilization Project Kids’ Inpatient Database that tested hypotheses guided by the conceptual framework of the Fundamental Cause Theory. There were two separate samples analyzed representing the common forms of childhood leukemia: the sample of lymphoblastic leukemia consisted of 28914 cases, and the sample of acute myeloid leukemia consisted of 2902 cases. Each case represented a pediatric hospitalization that took place in the United States in the year 2016. Logistic regression analyses revealed the risk for severe sepsis in Hispanic children was significantly greater than that of White children in both the acute lymphoid leukemia and the acute myeloid leukemia groups. Asian and Black children with acute lymphoid leukemia were found to be at significantly increased risk for high-cost hospitalizations, compared to White children.

This study provided evidence that the occurrence of life-threatening infections in hospitalized children with leukemia is a potential contributor to the disparate rates of survival and worthy of further investigation. Additional research should be conducted with the goal of developing an explanatory model for these disparities that can be used to improve nursing care of this vulnerable population.
Subject (authority = RUETD)
Topic
Nursing
Subject (authority = LCSH)
Topic
Leukemia in children -- Social aspects
Subject (authority = LCSH)
Topic
Leukemia -- Infections -- Social aspects
Subject (authority = LCSH)
Topic
Discrimination in medical care
Subject (authority = LCSH)
Topic
Health and race
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_9667
PhysicalDescription
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application/pdf
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text/xml
Extent
1 online resource (ix, 110 pages)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
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TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-mmt5-2551
Genre (authority = ExL-Esploro)
ETD doctoral
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Savage
GivenName
Beth
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-04-02 20:57:58
AssociatedEntity
Name
Beth Savage
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2019-04-08T17:05:43
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2019-04-08T21:05:05
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