Staff View
Synthesis, characterization and applications of polymeric emulsions for dual-drug delivery

Descriptive

TitleInfo
Title
Synthesis, characterization and applications of polymeric emulsions for dual-drug delivery
Name (type = personal)
NamePart (type = family)
Barai
NamePart (type = given)
Mayur Dnyaneshwar
NamePart (type = date)
1992-
DisplayForm
Mayur Dnyaneshwar Barai
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Tomassone
NamePart (type = given)
Silvina
DisplayForm
Silvina Tomassone
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Shapley
NamePart (type = given)
Nina
DisplayForm
Nina Shapley
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Dutt
NamePart (type = given)
Meenakshi
DisplayForm
Meenakshi Dutt
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
DateOther (qualifier = exact); (type = degree)
2019-05
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
Developing a novel smart material with tunable properties and multiple functionalities is of great interest in scientific community. Janus particles exhibit many unique chemical and physical properties due to their two distinct surfaces. They are in great demand for diverse applications across many fields including pharmaceutical, electronics, biomedical engineering (affinity with human endothelial cells was reported), magnetolythic therapy, etc. As a drug delivery carrier, Janus particles offer a platform for co-encapsulating drugs with different solubility and release kinetics. This study investigated the effects of solvents and surfactants on nanosuspensions formulation by emulsion-diffusion method. Model Biopharmaceutical Classification System (BCS) class II drug, ibuprofen was used in the preparation of nanosuspensions using three different water miscible solvents and blends of different nonionic surfactants. Surfactants with similar chemical structures but opposing hydrophilicities act synergistically. This study shows that for any set of low HLB and high HLB surfactants systems, combination of surfactants with HLB value near the mid-point produces most efficient and stable nanosuspensions. It is observed that for any combination of nonionic surfactants, the smallest particle size is achieved when surfactants with equal amounts are incorporated.
We have also performed a different study focused on a novel method of double emulsion for coencapsulation and staggered release of hydrophobic and hydrophilic drug from PLGA/PCL Janus particles were investigated. Acetaminophen (APAP) and Naproxen (NPX) were chosen as the model hydrophilic and hydrophobic drug pair for encapsulation method and drug release. Due to its poor oil solubility and tendency to escape to the outer aqueous phase, it needs a special modification during the emulsification process. Three different strategies were employed for incorporating hydrophilic drugs: a) O/W emulsion with partially-water miscible solvent, b) O/W emulsion with methanol as a co-solvent, and c) W/O/W double emulsion. Encapsulation efficiencies, percent drug loading and differential drug release kinetics were measured and compared for different methods of synthesis. It was observed that the double emulsion method resulted in the highest encapsulation efficiency, drug loading of the hydrophilic drug and highest concentration of drug release over the period of time.
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject (authority = LCSH)
Topic
Emulsions (Pharmacy) -- Synthesis
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_9854
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vi, 35 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-mqmt-vc58
Genre (authority = ExL-Esploro)
ETD graduate
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Barai
GivenName
Mayur
MiddleName
Dnyaneshwar
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-04-12 16:00:49
AssociatedEntity
Name
Mayur Barai
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-06-15T14:22:00
CreatingApplication
Version
1.4
Back to the top
Version 8.3.13
Rutgers University Libraries - Copyright ©2021