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A phantom based study of short-wave infrared emitting nanocomposites as contrast agents for fluorescence guided surgery

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TitleInfo
Title
A phantom based study of short-wave infrared emitting nanocomposites as contrast agents for fluorescence guided surgery
Name (type = personal)
NamePart (type = family)
Berger
NamePart (type = given)
Marissa S.
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Marissa S. Berger
Role
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author
Name (type = personal)
NamePart (type = family)
Pierce
NamePart (type = given)
Mark C
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Mark C Pierce
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Advisory Committee
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chair
Name (type = personal)
NamePart (type = family)
Boustany
NamePart (type = given)
Nada
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Nada Boustany
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Advisory Committee
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internal member
Name (type = personal)
NamePart (type = family)
Hacihaliloglu
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Ilker
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Ilker Hacihaliloglu
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Advisory Committee
Role
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internal member
Name (type = corporate)
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Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
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School of Graduate Studies
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school
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Text
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theses
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2019
DateOther (qualifier = exact); (type = degree)
2019-05
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2019
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
Accurate, real-time detection and characterization of cancerous lesions is essential for effective surgical resection that both minimizes the chance of recurrence and preserves healthy tissue. In multiple ongoing clinical trials, optically-guided surgical techniques are utilizing fluorescent probes that emit light in the near infrared (NIR) window. Use of NIR light is motivated by lower scattering and autofluorescence in biological tissues than UV or visible light which results in improved imaging depth, contrast, and resolution. Because scattering monotonically decreases with increasing wavelength, several groups have hypothesized that probes emitting at the longer wavelengths in the short-wave infrared (SWIR) window may enable even deeper tissue imaging and greater resolution / contrast.
This thesis is focused on engineering an imaging system for fluorescence guided surgery in small animal models using SWIR-emitting human serum albumin encapsulated rare-earth nanocomposites (ReANCs). LabVIEW software controls the illumination, scanning, and imaging hardware components and provides real-time visualization of SWIR emissions overlaid on anatomical (white light) images. A separate Matlab graphical user interface (GUI) was developed to enable quantitative post-processing of images acquired from the SWIR platform.
To validate the SWIR imager, a phantom study comparing the attainable imaging depth and resolution when using ReANCs versus the FDA-approved NIR fluorophore indocyanine green (ICG) versus white light was conducted. Tissue-mimicking gelatin phantoms were created with embedded agarose inclusions containing the contrast agent of interest. Inclusion depth, size, and shape were all varied, and inclusion contrast was quantified from SWIR and NIR images of the intact phantoms. Post-imaging, the inclusions were resected under SWIR, NIR, or white light guidance. The resected inclusions and inclusion cavities were then imaged to analyze resection accuracy for each guidance method.
A pilot in vivo animal study was performed using female athymic homozygous nude mice injected with Erbium-doped ReANCs. Imaging with the SWIR setup provided insight into future animal work. The cumulative findings of this thesis lay the groundwork for the design of a real-time imager that facilitates fluorescence-guided, deep tissue surgery, which has the potential to improve accuracy of tumor resection and decrease the chance of cancer recurrence.
Subject (authority = local)
Topic
Optical imaging
Subject (authority = RUETD)
Topic
Biomedical Engineering
Subject (authority = LCSH)
Topic
Diagnostic imaging
Subject (authority = LCSH)
Topic
Near infrared spectroscopy
RelatedItem (type = host)
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
Identifier
ETD_9730
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application/pdf
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text/xml
Extent
1 online resource (xiv, 85 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-489t-6e96
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

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The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Berger
GivenName
Marissa
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-04-09 09:32:15
AssociatedEntity
Name
Marissa Berger
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2019-04-04T17:36:49
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-04-04T17:36:49
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