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Effect of Staphylococcal enterotoxin A and tumor necrosis factor alpha on exploratory behaviors toward novel stimuli
Descriptive
TitleInfo
Title
Effect of Staphylococcal enterotoxin A and tumor necrosis factor alpha on exploratory behaviors toward novel stimuli
Name
(type = personal)
NamePart
(type = family)
Chang
NamePart
(type = given)
Qing
NamePart
(type = date)
1989-
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Qing Chang
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(authority = RULIB)
author
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(type = personal)
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Kusnecov
NamePart
(type = given)
Alexander
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Alexander Kusnecov
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Advisory Committee
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chair
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(type = personal)
NamePart
(type = family)
Wagner
NamePart
(type = given)
George
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George Wagner
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Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Matzel
NamePart
(type = given)
Louis
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Louis Matzel
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Advisory Committee
Role
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(authority = RULIB)
internal member
Name
(type = personal)
NamePart
(type = family)
Anisman
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(type = given)
Hymie
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Hymie Anisman
Affiliation
Advisory Committee
Role
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(authority = RULIB)
outside member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
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NamePart
School of Graduate Studies
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school
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Text
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theses
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2019
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2019-05
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2019
Language
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English
Abstract
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Staphylococcal enterotoxin A (SEA) is a superantigen that stimulates T cells. It has well-characterized neurobiological and endocrine effects, which have been shown to rely on the cytokine, tumor necrosis factor alpha (TNFα). We tested the effect of SEA and TNFα on mouse exploratory behavior toward a novel stimulus using multiple protocols. To test the effects of SEA challenge, novel object stimuli with and without a familiar object were presented to male C57BL/6 mice, and the mice were given one or more days to explore the familiar object before the test. When exposed to a novel object together with a familiar object, SEA-challenged mice displayed more immobile episodes and duration when observing the novel object. However, when the animals were given multiple trials to explore the novel object, the increased immobility was reduced. When the animals were tested in a different procedure involving a larger open field apparatus without the presence of the familiar object, mice showed less exploration to the novel object when treated with SEA. This was observed to be age-dependent, with older mice (10 months) showing a greater effect relative to younger mice (3 months). SEA stimulates T-cells and increases the level of tumor necrosis factor alpha (TNF-α). Consequently, we conducted additional experiments in which the effects of central TNFα infusion was tested in a series of conditions looking at an object, food and social mate novelty. The results showed that TNF-α increased the exploratory behavior in the open field with the presence of a novel object, and decreased exploration and consumption of a novel diet. Overall, it was concluded that TNF-α, a major cytokine released in response to T-cell activation by SEA, affects the exploratory behavior of mice in multiple dimensions. Future studies should determine whether SEA effects involve TNF actions operating within the brain.
Subject
(authority = local)
Topic
SEA
Subject
(authority = RUETD)
Topic
Psychology
Subject
(authority = LCSH)
Topic
Staphylococcal infections
Subject
(authority = LCSH)
Topic
Tumor necrosis factor
RelatedItem
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Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_9626
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text/xml
Extent
1 online resource (xi, 126 pages) : illustrations
Note
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Ph.D.
Note
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Includes bibliographical references
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Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-0pzt-nt17
Genre
(authority = ExL-Esploro)
ETD doctoral
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Rights
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The author owns the copyright to this work.
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Name
FamilyName
Chang
GivenName
Qing
Role
Copyright Holder
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Type
Permission or license
DateTime
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2019-03-29 08:58:38
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Qing Chang
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Affiliation
Rutgers University. School of Graduate Studies
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Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Embargo
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2019-05-31
DateTime
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2021-05-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2021.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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