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Nanoparticle mediated release from polymersomes using ultrafast irradiation

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TitleInfo
Title
Nanoparticle mediated release from polymersomes using ultrafast irradiation
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Robinson
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Abby
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Abby Robinson
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author
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Zhu
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Hao
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Hao Zhu
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Advisory Committee
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chair
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Griepenburg
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Julianne
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Julianne Griepenburg
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internal member
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O'Malley
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Sean M.
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Sean M O'Malley
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internal member
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Fu
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Jinglin
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Jinglin Fu
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Rutgers University
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degree grantor
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Camden Graduate School
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school
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theses
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2019
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2019-05
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2019
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eng
Abstract
The self-assembly of amphiphilic diblock copolymers into polymeric vesicles, commonly known as polymersomes, has attracted significant research interest due the broad applicability in various fields ranging from drug delivery to nanoreactors. Polymersomes are fully synthetic robust vesicles comprised of a hydrophilic core and bilayer, hydrophobic membrane; this provides the ability for stable, dual-encapsulation of a variety of molecules within the two regions. While most diblock copolymers yield vesicles that are inherently insensitive to stimuli, efforts have been made to design polymersomes that rupture in response to temperature, pH, and light such that encapsulated cargo can be released on demand. Light is a particularly attractive trigger for initiating cargo release as it can be controlled in a high spatiotemporal fashion and can be minimally damaging and deeply penetrating in biological systems. In this work, methods have been developed for triggered encapsulant release using ultrafast, single-pulse irradiation with visible and near infrared light to provide a non-invasive method of achieving spatial and temporal control. Gold nanoparticles (AuNPs) have been incorporated into the vesicle membrane as photosensitizers to allow for wavelength specific vesicle rupture congruent with the localized surface plasmon resonance (LSPR) of the particle. Thus, the encapsulation of gold nanorods provides the ability to shift the polymersome response wavelength to the near-infrared. Initial studies were performed on micron-scale polymersomes to facilitate release studies at the single vesicle level. Additonally, scale down to the nano-regime was optimized for future applications in biomedical systems where diameters range from 80-200 nm deemed optimal for in-vivo drug delivery.
Subject (authority = local)
Topic
Polymersomes
Subject (authority = RUETD)
Topic
Chemistry
Subject (authority = ETD-LCSH)
Topic
Nanoparticles
Subject (authority = ETD-LCSH)
Topic
Medical microbiology
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Rutgers University Electronic Theses and Dissertations
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ETD_9986
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1 online resource (ix, 119 pages) : illustrations
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M.S.
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Includes bibliographical references
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Camden Graduate School Electronic Theses and Dissertations
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rucore10005600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-hnj3-yn81
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

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The author owns the copyright to this work.
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Robinson
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Abby
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Permission or license
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2019-05-06 14:15:14
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Name
Abby Robinson
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Rutgers University. Camden Graduate School
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2019-05-31
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2020-05-30
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Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2020.
Copyright
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Copyright protected
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Open
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Permission or license
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