DescriptionAutism Spectrum Disorder (ASD) is a lifelong neurological disorder affecting 1 in 59 individuals (Centers for Disease Control and Prevention [CDC], 2018). ASD is highly comorbid with anxiety and core symptomology often also leads to deficits across all domains of adaptive functioning (Simonoff et al., 2008). However, little is known about the intersectionality between anxiety, adaptive function, and the core symptoms of autism. This study aims to identify whether anxiety has a unique impact on adaptive functioning in ASD, and if so, which domains it most impacts. Cross-sectional data (n= 367) previously collected at the Center for Autism Research were analyzed. Vineland Adaptive Behavior Scale (VABS; Sparrow, Cicchetti & Balla, 2005) scores were predicted from the interaction between the Social Responsiveness Scale (SRS; Constantino et al., 2000) and the Screening for Children Anxiety Related Disorders-Revised (SCARED; Birmaher et al., 1997) via multiple regression model analyses. No significant results were found, suggesting that anxiety may not play a unique role in predicting adaptive functioning above and beyond core ASD symptoms. Implications for future research, treatment, and intervention are discussed.