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Effect of chlorine water consumption on phenotypic and microbiome development
Descriptive
TitleInfo
Title
Effect of chlorine water consumption on phenotypic and microbiome development
Name
(type = personal)
NamePart
(type = family)
Nathan
NamePart
(type = given)
Aishwarya
NamePart
(type = date)
1995-
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Aishwarya Nathan
Role
RoleTerm
(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Dominguez-Bello
NamePart
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Maria Gloria
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Maria Gloria Dominguez-Bello
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
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NamePart
Rutgers University
Role
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(authority = RULIB)
degree grantor
Name
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NamePart
School of Graduate Studies
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school
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Text
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theses
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2019
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(type = degree)
2019-05
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2019
Language
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(authority = ISO 639-3:2007);
(type = text)
English
Abstract
(type = abstract)
Urbanization sanctions the use of sanitation and health practices that have helped to control the transmission of infectious diseases. One of the widely used methods of disinfection is water chlorination, which achieves the purpose of killing pathogenic microbes, but may could also affect the human microbiome. In this pilot study, experiments were conducted in mice, to investigate the effects of chlorinated water consumption from early life, on growth and microbiome development. The experiment involved 10 pregnant dams, 5 in each group, and it was repeated twice (cohort 1 and 2). Body weight changes were measured, and fecal samples were collected weekly for microbiome structure determination. The results showed that there was a significantly higher developmental weight gain in mice (both males and females) that consumed chlorinated water, and the effect was consistent in the two cohorts. The effect was observed after weaning, when the young animals started drinking the chlorinated water. Chlorination significantly altered the microbiome, lowering fecal alpha diversity. The results suggest that drinking chlorinated water at early ages may significantly affect development, by microbiome-meditated mechanisms, with important implications for human health.
Subject
(authority = local)
Topic
Urbanization
Subject
(authority = RUETD)
Topic
Microbial Biology
Subject
(authority = LCSH)
Topic
Chlorine -- Physiological effect
Subject
(authority = LCSH)
Topic
Water -- Purification -- Chlorination -- Physiological effect
RelatedItem
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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(type = RULIB)
ETD
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ETD_9829
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application/pdf
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text/xml
Extent
1 online resource (vii, 43 pages) : illustrations
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-a9s4-kp69
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Nathan
GivenName
Aishwarya
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2019-04-12 12:08:40
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Name
Aishwarya Nathan
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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1.7
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2019-05-07T10:44:18
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2019-05-07T10:44:18
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