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The phytochemical investigation, breeding and arthropod repellent efficacy of Nepeta cataria
Descriptive
TitleInfo
Title
The phytochemical investigation, breeding and arthropod repellent efficacy of Nepeta cataria
Name
(type = personal)
NamePart
(type = family)
Reichert
NamePart
(type = given)
William J.
NamePart
(type = date)
1987-
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William J. Reichert
Role
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(authority = RULIB)
author
Name
(type = personal)
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Simon
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(type = given)
James Edward
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James Edward Simon
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Advisory Committee
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chair
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Rutgers University
Role
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degree grantor
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School of Graduate Studies
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school
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theses
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2019
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2019-05
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English
Abstract
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While notoriously known for inducing the euphoric effect on felines, Nepeta cataria (catnip) is emerging as a natural product and source of a variety of compounds useful for human health. Nepeta cataria produces essential oil in glandular trichomes on leaf and floral surfaces as well as a variety of non-volatile compounds that have been shown to be medicinally active. This plant species is becoming increasingly popular for its use as a feline attractant, medicinal therapeutic and as a naturally sourced insect repellent. This research shows that the bioactives in catnip can be as effective as a repellant against mosquitoes and ticks as DEET. With the new developments and current use of catnip as a natural product, this dissertation focuses on standardizing plants and extracts for applications of its bioactives for emerging areas of public health and interest. An investigation into the genetic inheritance of the key bioactive compound nepetalactone, was conducted as a foundational base for plant breeding to develop improved N. cataria populations. Breeding was conducted to select for increased biomass, total essential oil and increased nepetalactone production in the aromatic volatile oil. Two new plant varieties were developed, cv. CR9 and cv. CR3 each with significantly improved total essential oil and as rich sources of nepetalactone. Associated studies examining where such bioactive compounds accumulate, as well as the antioxidant and anti-inflammatory activities were conducted. This dissertation then focused on examining the repellency efficacy that N. cataria population’s essential oils have against disease vectoring insects such as A. aegypti mosquitoes and D. variabilis as well as I. scapularis ticks by developing dose response curves to determine the minimum concentration required of the essential to achieve complete repellency of the disease vectors. Finally, N. cataria essential oil was incorporated into a series of formulations to extend the duration of acceptable repellency of the essential oil while also examining the skin toxicity associated with one of the effective formulations.
Subject
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Topic
Nepeta cataria
Subject
(authority = RUETD)
Topic
Plant Biology
Subject
(authority = LCSH)
Topic
Catnip -- Breeding
Subject
(authority = LCSH)
Topic
Insect baits and repellents
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Rutgers University Electronic Theses and Dissertations
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ETD_9833
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1 online resource (xxiii, 198 pages) : illustrations
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Ph.D.
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Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
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doi:10.7282/t3-wv8r-bb85
Genre
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ETD doctoral
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Reichert
GivenName
William
MiddleName
J.
Role
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Type
Permission or license
DateTime
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2019-04-12 10:11:58
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Name
William Reichert
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Affiliation
Rutgers University. School of Graduate Studies
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2019-05-31
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2021-05-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 30th, 2021.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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