LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
Current literature suggests that, in general, RRSO is valuable for women who carry a BRCA1/BRCA2 mutation, but there is limited literature regarding the benefits and risks of RRSO for BRCA1/BRCA2 positive women over the age of 75. National Comprehensive Cancer Network (NCCN) guidelines recommend risk-reducing salpingo-oophorectomy (RRSO) for women with a BRCA1 mutation by the age of 35-40 and women with a BRCA2 mutation to have a RRSO by the age of 40-45 or after the completion of childbearing. NCCN does not provide upper age limit recommendations for RRSO and ovarian cancer management. Therefore, limitations to current studies and lack of professional guidelines for BRCA1/ BRCA2 positive women over the age of 75 pretenses the question if RRSO is an appropriate medical management option for this patient population. A survey was sent out through the National Society of Genetic Counselors (NSGC) to genetic counselors registered to the Cancer Special Interest Group (SIG) email listserv to investigate if cancer genetic counselors feel RRSO is an appropriate medical management option for women over the age of 75 who carry a BRCA1/BRCA2 mutation, and if they feel confident counseling this patient population. In addition, it explored if differing patient factors influence cancer genetic counselors’ feelings toward RRSO as an appropriate option and what resources are used when counseling this patient population. Overall, the majority of survey respondents (70%) reported that they felt RRSO was appropriate for a 77-year-old woman who carries a BRCA1 mutation. Answers differed significantly when the patient was 85-years-old or had comorbidities such as hypertension and type 2 diabetes. Overall, there is inconsistency in survey respondents’ opinions regarding RRSO for this patient population, and our study results found this to be particularly true when counseling BRCA1/BRCA2 positive patients who are 85-years-old or have comorbid conditions. Additional research and development of professional guidelines are needed to help standardize care in regard to ovarian cancer risk reduction for this patient population.
Subject (authority = local)
Topic
Genetic counselor
Subject (authority = RUETD)
Topic
Microbiology and Molecular Genetics
Subject (authority = LCSH)
Topic
Genetic counseling
Subject (authority = LCSH)
Topic
Older women -- Health risk assessment
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_9683
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (iv, 34 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.