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Measurement of the surface energy of raw and lubricated lactose powders by inverse gas chromatography

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TitleInfo
Title
Measurement of the surface energy of raw and lubricated lactose powders by inverse gas chromatography
Name (type = personal)
NamePart (type = family)
Xu
NamePart (type = given)
Jiteng
DisplayForm
Jiteng Xu
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Callegari
NamePart (type = given)
Gerardo
DisplayForm
Gerardo Callegari
Affiliation
Advisory Committee
Role
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chair
Name (type = personal)
NamePart (type = family)
Drazer
NamePart (type = given)
German
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German Drazer
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = personal)
NamePart (type = family)
Shapley
NamePart (type = given)
Nina
DisplayForm
Nina Shapley
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
co-chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2019
DateOther (encoding = w3cdtf); (qualifier = exact); (type = degree)
2019-05
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2019
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract
Engineers and pharmacists have shown that in particle processing operations such as milling, granulation, crystallization and powder mixing, the surface energy of the starting, intermediate or final products is a key factor to understand the outcome of the operation and the final product performance. Since its establishment in the 1940s, inverse gas chromatography (IGC) is a powerful, sensitive and relatively fast technique for characterizing the surface properties of pharmaceutical powders. The feasibility of using IGC to investigate changes in surface energy of pharmaceutical powders depending on particle size of the powder and on the magnitude of shear strain applied to a pharmaceutical blend is considered in this thesis. Two powder materials, an excipient and a lubricant, are used. The excipient is lactose monohydrate powder sieved to obtain particles in the following size ranges: 38-45, 45-53, 53-63, 63-75, 75-90, and 90-106µm. The lubricant is magnesium stearate (MgSt). The blends were mixed using a V-blender and a controlled amount of mechanical shear strain was applied to the blend by using an ad-hoc modified Couette shear cell. It was found that the surface energy of lactose has no significant dependence on particle size. We also show that there is a measurable reduction in the dispersive energy of lactose-MgSt blends.
Subject (authority = ETD-LCSH)
Topic
Lactose
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject (authority = ETD-LCSH)
Topic
Inverse gas chromatography
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Identifier
ETD_9806
Identifier (type = doi)
doi:10.7282/t3-vxje-8972
PhysicalDescription
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InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 39 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = funding)
This work was partially supported by the National Science Foundation Grant no. CMMI-1538380.
Location
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Grant award
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Funder
Name
National Science Foundation
AssociatedObject
Type
Grant number
Name
CMMI-1538380
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Xu
GivenName
Jiteng
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-04-12 15:54:31
AssociatedEntity
Name
Jiteng Xu
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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windows xp
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-06-17T20:55:11
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1.3
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