LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract
Engineers and pharmacists have shown that in particle processing operations such as milling, granulation, crystallization and powder mixing, the surface energy of the starting, intermediate or final products is a key factor to understand the outcome of the operation and the final product performance. Since its establishment in the 1940s, inverse gas chromatography (IGC) is a powerful, sensitive and relatively fast technique for characterizing the surface properties of pharmaceutical powders. The feasibility of using IGC to investigate changes in surface energy of pharmaceutical powders depending on particle size of the powder and on the magnitude of shear strain applied to a pharmaceutical blend is considered in this thesis. Two powder materials, an excipient and a lubricant, are used. The excipient is lactose monohydrate powder sieved to obtain particles in the following size ranges: 38-45, 45-53, 53-63, 63-75, 75-90, and 90-106µm. The lubricant is magnesium stearate (MgSt). The blends were mixed using a V-blender and a controlled amount of mechanical shear strain was applied to the blend by using an ad-hoc modified Couette shear cell. It was found that the surface energy of lactose has no significant dependence on particle size. We also show that there is a measurable reduction in the dispersive energy of lactose-MgSt blends.
Subject (authority = ETD-LCSH)
Topic
Lactose
Subject (authority = RUETD)
Topic
Chemical and Biochemical Engineering
Subject (authority = ETD-LCSH)
Topic
Inverse gas chromatography
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Identifier
ETD_9806
Identifier (type = doi)
doi:10.7282/t3-vxje-8972
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 39 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
Note (type = funding)
This work was partially supported by the National Science Foundation Grant no. CMMI-1538380.
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
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