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Autism spectrum disorder symptoms from 2 to 19: implications for diagnosing adolescents and young adults

Descriptive

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Text
TitleInfo
Title
Autism spectrum disorder symptoms from 2 to 19: implications for diagnosing adolescents and young adults
Identifier (type = pmcid)
PMC6600818
Name (authority = orcid); (authorityURI = http://id.loc.gov/vocabulary/identifiers/orcid.html); (type = personal); (valueURI = http://orcid.org/0000-0003-0750-823X)
NamePart (type = family)
Bal
NamePart (type = given)
Vanessa
Affiliation
Clinical Psychology (Graduate School of Applied and Professional Psychology, GSAPP), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Kim
NamePart (type = given)
So-Hyun
Affiliation
Weill Cornell Medicine
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Fok
NamePart (type = given)
Megan
Affiliation
Clinical Psychology (Graduate School of Applied and Professional Psychology, GSAPP), Rutgers University
Role
RoleTerm (authority = marcrt); (type = text)
author
Name (type = personal)
NamePart (type = family)
Lord
NamePart (type = given)
Catherine
Affiliation
Weill Cornell Medicine
Role
RoleTerm (authority = marcrt); (type = text)
author
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NamePart
Clinical Psychology (Graduate School of Applied and Professional Psychology, GSAPP)
Name (authority = RutgersOrg-School); (type = corporate)
NamePart
Graduate School of Applied and Professional Psychology (GSAPP)
Genre (authority = RULIB-FS)
Article, Refereed
Genre (authority = NISO JAV)
Accepted Manuscript (AM)
Note (type = peerReview)
Peer reviewed
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
Abstract (type = Abstract)
This study explored change in social-communicative symptoms in 140 individuals with childhood Autism Spectrum Disorder (ASD) diagnoses. Trajectories of caregiver-reported social-communicative symptoms were examined for three groups (verbal, delayed speech, minimally verbal) from ages 2 to 19 years. Groups showed comparable levels of social-communicative impairment at 2 and significant decreases in overall symptom levels across the 17-year period (p<.001). Across three subdomains, main effects of time and language (p<.001) reflected patterns of overall improvement, though children with more impaired language tended to have more caregiver-reported symptoms relative to verbal peers. A significant time-by-language interaction (p<.001) reflected that trajectories of socioemotional reciprocity symptoms differed according to patterns of language development. In contrast, improvements in the nonverbal communication domain were seen across language groups, whereas deficits in the development and maintenance of relationships improved for only verbal children. Verbal adults showed significant reductions in the prevalence of several symptoms exhibited during childhood. Improvements suggest that symptoms indicative of ASD in young children may no longer be diagnostic markers in adolescents and adults. Relative stability of several items suggests that impaired facial expression may be a core ASD symptom that warrants more systematic study across the lifespan. Research investigating the manifestation of ASD in older individuals is needed to foster development of appropriate assessment tools and interventions. Differential relationships to developmental factors within the broader social-communication domain underscores a need to focus on more narrowly defined symptom constructs when exploring links between pathophysiology and observable phenotypes.
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
PhysicalDescription
InternetMediaType
application/pdf
Extent
1 online resource (41 pages) : illustrations
Subject (authority = local)
Topic
Adolescent
Subject (authority = local)
Topic
Adult
Subject (authority = local)
Topic
Symptom
Subject (authority = local)
Topic
Longitudinal
Extension
DescriptiveEvent
Type
Citation
DateTime (encoding = w3cdtf)
2019
AssociatedObject
Name
Autism Research
Type
Journal
Relationship
Has part
Detail
89-99
Identifier (type = volume and issue)
12(1)
Reference (type = url)
https://doi.org/10.1002/aur.2004
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Vanessa H. Bal, PhD
AssociatedObject
Type
Grant number
Name
K23MH115166-01
Extension
DescriptiveEvent
Type
Grant award
AssociatedEntity
Role
Funder
Name
National Institutes of Health
AssociatedEntity
Role
Originator
Name
Catherine Lord, PhD
AssociatedObject
Type
Grant number
Name
R01-MH081873
RelatedItem (type = host)
TitleInfo
Title
Bal, Vanessa
Identifier (type = local)
rucore30258400001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-6bva-6a41
Genre (authority = ExL-Esploro)
Accepted Manuscript
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Rights

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Copyright for scholarly resources published in RUcore is retained by the copyright holder. By virtue of its appearance in this open access medium, you are free to use this resource, with proper attribution, in educational and other non-commercial settings. Other uses, such as reproduction or republication, may require the permission of the copyright holder.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
RightsEvent
Type
Permission or license
AssociatedObject
Type
License
Name
Multiple author license v. 1
Detail
I hereby grant to Rutgers, The State University of New Jersey (Rutgers) the non-exclusive right to retain, reproduce, and distribute the deposited work (Work) in whole or in part, in and from its electronic format, without fee. This agreement does not represent a transfer of copyright to Rutgers.Rutgers may make and keep more than one copy of the Work for purposes of security, backup, preservation, and access and may migrate the Work to any medium or format for the purpose of preservation and access in the future. Rutgers will not make any alteration, other than as allowed by this agreement, to the Work.I represent and warrant to Rutgers that the Work is my original work. I also represent that the Work does not, to the best of my knowledge, infringe or violate any rights of others.I further represent and warrant that I have obtained all necessary rights to permit Rutgers to reproduce and distribute the Work and that any third-party owned content is clearly identified and acknowledged within the Work.By granting this license, I acknowledge that I have read and agreed to the terms of this agreement and all related RUcore and Rutgers policies.
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