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In vivo characterization of a prevascularized, load-bearing scaffold for bone regeneration
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Buckley, Christian E.. In vivo characterization of a prevascularized, load-bearing scaffold for bone regeneration. Retrieved from https://doi.org/doi:10.7282/t3-82vf-j514

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TitleIn vivo characterization of a prevascularized, load-bearing scaffold for bone regeneration
NameBuckley, Christian E. (author); Freeman, Joseph (chair); Shreiber, David (internal member); Parekkadan, Biju (internal member); Rutgers University; School of Graduate Studies
Date Created2019
Other Date2019-10 (degree)
SubjectBiomedical Engineering, Tissue scaffolds, Bone regeneration
Extent1 online resource (vii, 36 pages) : illustrations
DescriptionDue to the increasing number of orthopedic injuries occurring each year, there is a critical need for better treatments of improperly healed fractures. Today’s treatments, such as autografts, allografts, and biocompatible ceramics, all have their own drawbacks, including donor site morbidity, disease transmission, and poor degradation rates. To circumvent these problems, bone tissue engineering utilizes various biocompatible materials and cells to mimic native bone while new tissue is created. We have developed a prevascularized tissue-engineered scaffold that combines two stereoisomers of polylactic acid and hydroxyapatite to simultaneously entice osteogenic and vascular differentiation of mesenchymal stem cells. In this study, we have implanted these scaffolds into a radial defect model in New Zealand white rabbits for 8 weeks. Radiographic images at 4 and 8 weeks have shown considerable remodeling occurring at the implant site and stable implants throughout the study. Results from micro computed tomography showed a large amount of new bone growth into and around the scaffold, both quantitatively and qualitatively. Mechanical testing resulted in similar amounts of force required to remove the scaffold from the implant site when compared to the allograft control. Finally, histological analysis showed collagen deposition into and around the scaffolds with many cells present throughout. Signs of vasculature can be seen in the osteons but there is little evidence of angiogenesis. The tissue-engineered scaffold used in this study was comparable to an allograft, one of today’s gold standards, and shows potential to be a clinically useful alternative.
NoteM.S.
NoteIncludes bibliographical references
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/t3-82vf-j514
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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