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In vivo characterization of a prevascularized, load-bearing scaffold for bone regeneration

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TitleInfo
Title
In vivo characterization of a prevascularized, load-bearing scaffold for bone regeneration
Name (type = personal)
NamePart (type = family)
Buckley
NamePart (type = given)
Christian E.
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Christian E. Buckley
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RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Freeman
NamePart (type = given)
Joseph
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Joseph Freeman
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Advisory Committee
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chair
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NamePart (type = family)
Shreiber
NamePart (type = given)
David
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David Shreiber
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Advisory Committee
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internal member
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Parekkadan
NamePart (type = given)
Biju
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Biju Parekkadan
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
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Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (qualifier = exact)
2019
DateOther (encoding = w3cdtf); (qualifier = exact); (type = degree)
2019-10
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
Due to the increasing number of orthopedic injuries occurring each year, there is a critical need for better treatments of improperly healed fractures. Today’s treatments, such as autografts, allografts, and biocompatible ceramics, all have their own drawbacks, including donor site morbidity, disease transmission, and poor degradation rates. To circumvent these problems, bone tissue engineering utilizes various biocompatible materials and cells to mimic native bone while new tissue is created. We have developed a prevascularized tissue-engineered scaffold that combines two stereoisomers of polylactic acid and hydroxyapatite to simultaneously entice osteogenic and vascular differentiation of mesenchymal stem cells. In this study, we have implanted these scaffolds into a radial defect model in New Zealand white rabbits for 8 weeks. Radiographic images at 4 and 8 weeks have shown considerable remodeling occurring at the implant site and stable implants throughout the study. Results from micro computed tomography showed a large amount of new bone growth into and around the scaffold, both quantitatively and qualitatively. Mechanical testing resulted in similar amounts of force required to remove the scaffold from the implant site when compared to the allograft control. Finally, histological analysis showed collagen deposition into and around the scaffolds with many cells present throughout. Signs of vasculature can be seen in the osteons but there is little evidence of angiogenesis. The tissue-engineered scaffold used in this study was comparable to an allograft, one of today’s gold standards, and shows potential to be a clinically useful alternative.
Subject (authority = RUETD)
Topic
Biomedical Engineering
Subject (authority = LCSH)
Topic
Tissue scaffolds
Subject (authority = LCSH)
Topic
Bone regeneration
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
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ETD_10225
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application/pdf
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Extent
1 online resource (vii, 36 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
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Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-82vf-j514
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Buckley
GivenName
Christian
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-09-07 09:43:35
AssociatedEntity
Name
Christian Buckley
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
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Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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2019-09-07T09:36:41
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2019-09-07T09:36:41
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