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The relationship between retinal and cognitive functioning in schizophrenia

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TitleInfo
Title
The relationship between retinal and cognitive functioning in schizophrenia
Name (type = personal)
NamePart (type = family)
Demmin
NamePart (type = given)
Docia L.
NamePart (type = date)
1991-
DisplayForm
Docia L. Demmin
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Silverstein
NamePart (type = given)
Steven M
DisplayForm
Steven M Silverstein
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Shors
NamePart (type = given)
Tracey
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Tracey Shors
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Kusnecov
NamePart (type = given)
Alexander
DisplayForm
Alexander Kusnecov
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
DateOther (encoding = w3cdtf); (qualifier = exact); (type = degree)
2019-10
CopyrightDate (encoding = w3cdtf); (qualifier = exact)
2019
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
The retina may provide a unique window into brain structure and function as an accessible part of the central nervous system. Abnormalities in retinal cell structure and function have been associated with brain pathology (e.g., brain volume loss, cognitive impairment, functional disability) in several neuropsychiatric disorders (e.g., Multiple Sclerosis, Alzheimer’s disease, Parkinson’s disease). A number of prior studies using flash electroretinography (fERG) have observed a reduction in retinal cell activity in schizophrenia (SZ). Impairments in cognitive functioning are a core feature of SZ and deficits in executive control processes involving prefrontal cortex (PFC) activity (i.e., working memory, attention, executive functioning), are strong indicators of functional capacity. However, it is not known how anomalies in retinal cell signaling may relate to cognitive changes in SZ. This study examined whether retinal cell functioning is related to brain function, as indexed by cognitive function, in SZ, and if these relationships were stronger in particular domains (e.g., PFC dependent functions vs. less PFC dependent functions). Twenty-six SZ participants and 24 healthy controls (HC) completed an fERG protocol and cognitive test battery. fERG measurements included a-wave (photoreceptor cells), b-wave (bipolar-Müller cell cells), and oscillatory potential (OP; amacrine cells) amplitudes and implicit times. Cognitive tests assessed executive control processes such as attention/speed of information processing, behavior initiation, response inhibition, and working memory, and non-executive control processes such as emotion recognition and discrimination. fERG and cognitive test data were examined for between-group differences. The relationship between fERG variables and cognitive test scores within each group was assessed with Pearson correlations and hierarchical multiple regression analyses. Canonical correlations were also performed to determine if a set of fERG variables was significantly related to a set of cognitive functioning variables. Our results confirm those of prior studies demonstrating anomalies in a-wave and b-wave activity and lower cognitive test performance in SZ, in comparison to controls. In the HC group, a-wave amplitude was correlated with cognitive test scores and OP amplitude was related to cognitive test performance in the SZ group. However, overall, retinal cell activity did not appear to be strongly related to scores on cognitive tasks, regardless of whether or not they involved frontal brain regions. Thus, impairments in retinal and cognitive functioning may reflect distinct disease mechanisms in schizophrenia. Additional studies of larger sample sizes are needed in order to determine the similarity between retinal cell functioning and cognitive functioning in SZ.
Subject (authority = RUETD)
Topic
Psychology
Subject (authority = LCSH)
Topic
Schizophrenia -- Diagnosis
Subject (authority = LCSH)
Topic
Retina
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
Identifier
ETD_10164
PhysicalDescription
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application/pdf
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text/xml
Extent
1 online resource (viii, 49 pages) : illustrations
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-pxdg-g065
Genre (authority = ExL-Esploro)
ETD graduate
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Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Demmin
GivenName
Docia
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-08-12 15:11:43
AssociatedEntity
Name
Docia Demmin
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2020-05-01
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after May 1st, 2020.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical

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ETD
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windows xp
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1.4
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Mac OS X 10.13.6 Quartz PDFContext
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-08-29T18:36:23
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-08-29T18:36:23
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