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Bone turnover and GLP-1 respond to a putative α-glucosidase inhibitor
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Kreitman, Alexandra. Bone turnover and GLP-1 respond to a putative α-glucosidase inhibitor. Retrieved from https://doi.org/doi:10.7282/t3-nq29-ez30

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TitleBone turnover and GLP-1 respond to a putative α-glucosidase inhibitor
NameKreitman, Alexandra (author); Shapses, Sue A (chair); Watford, Malcolm (co-chair); Bello, Nicholas T (co-chair); Rutgers University; School of Graduate Studies
Date Created2019
Other Date2019-10 (degree)
SubjectNutritional Sciences, GLP-1, Glucagon-like peptide 1, Glucosidase inhibitors
Extent1 online resource (vii, 43 pages) : illustrations
DescriptionThe botanical, Salacia chinensis (SC), has α-glucosidase inhibitor (α-GI) properties that attenuates postprandial glycemic indices and increases secretion of glucagon-like peptide (GLP-1), a gut peptide that is associated with a reduced rate of bone resorption. A double-blind, placebo-controlled cross-over study was conducted to evaluate whether SC affected bone turnover and could be explained by changes in GLP-1. In this study, 21 healthy overweight/obese adults (body mass index: 29 ± 3.78 kg/m2; 21-59 years) received either placebo or SC with a fixed breakfast at each visit. A fasting blood sample was taken before and at 30-minute intervals after the meal to measure bone turnover markers as well as glycemic indices and gut peptides. Results indicated that SC attenuated the bone resorption marker, C-telopeptide of type I collagen (CTX), at 60, 90, and 120 minutes (p<0.05), and bone formation marker, osteocalcin (OC), at 180 minutes (p<0.05). In addition, SC lessened the rise in glucose compared with placebo whereas GLP-1 was increased at 60 minutes (p<0.05) with SC. Furthermore, GLP-1 and amylin were shown to be predictors of CTX. This study indicates that SC, known primarily to minimize the rise in postprandial glycemic indices, also markedly decreases postprandial bone resorption and is associated with a rise in GLP-1. Since SC attenuates postprandial bone resorption, longer term use could benefit bone health.
NoteM.S.
NoteIncludes bibliographical references
Genretheses, ETD graduate
Persistent URLhttps://doi.org/doi:10.7282/t3-nq29-ez30
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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