TY - JOUR TI - Bone turnover and GLP-1 respond to a putative α-glucosidase inhibitor DO - https://doi.org/doi:10.7282/t3-nq29-ez30 PY - 2019 AB - The botanical, Salacia chinensis (SC), has α-glucosidase inhibitor (α-GI) properties that attenuates postprandial glycemic indices and increases secretion of glucagon-like peptide (GLP-1), a gut peptide that is associated with a reduced rate of bone resorption. A double-blind, placebo-controlled cross-over study was conducted to evaluate whether SC affected bone turnover and could be explained by changes in GLP-1. In this study, 21 healthy overweight/obese adults (body mass index: 29 ± 3.78 kg/m2; 21-59 years) received either placebo or SC with a fixed breakfast at each visit. A fasting blood sample was taken before and at 30-minute intervals after the meal to measure bone turnover markers as well as glycemic indices and gut peptides. Results indicated that SC attenuated the bone resorption marker, C-telopeptide of type I collagen (CTX), at 60, 90, and 120 minutes (p<0.05), and bone formation marker, osteocalcin (OC), at 180 minutes (p<0.05). In addition, SC lessened the rise in glucose compared with placebo whereas GLP-1 was increased at 60 minutes (p<0.05) with SC. Furthermore, GLP-1 and amylin were shown to be predictors of CTX. This study indicates that SC, known primarily to minimize the rise in postprandial glycemic indices, also markedly decreases postprandial bone resorption and is associated with a rise in GLP-1. Since SC attenuates postprandial bone resorption, longer term use could benefit bone health. KW - Nutritional Sciences KW - GLP-1 KW - Glucagon-like peptide 1 KW - Glucosidase inhibitors LA - English ER -