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Therapeutic role of neurogenic transcription factors in spinal cord injury
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Patel, Misaal N.. Therapeutic role of neurogenic transcription factors in spinal cord injury. Retrieved from https://doi.org/doi:10.7282/t3-8w2j-kh03

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TitleTherapeutic role of neurogenic transcription factors in spinal cord injury
NamePatel, Misaal N. (author); Cai, Li (chair); Firestein, Bonnie (internal member); Pang, Zhiping (internal member); Kwan, Kelvin Y (outside member); Jiang, Peng (outside member); Rutgers University; School of Graduate Studies
Date Created2019
Other Date2019-10 (degree)
SubjectBiomedical Engineering, Spinal cord -- Wounds and injuries -- Treatment
Extent1 online resource (x, 100 pages) : illustrations
DescriptionSpinal cord injury (SCI) results in neuronal damage and glial scar formation, leading to loss of function and paralysis below the injury site. Although there are assistive devices in the market, there are no therapeutics that promote complete repair and regeneration after SCI. Major hurdles in neural regeneration include a limited level of neurogenesis in the adult spinal cord, an inflammatory microenvironment that inhibits neurogenesis, axon regeneration, neuronal relay formation, and myelination at the injury site. Promoting endogenous neural stem and progenitor cells (NSPCs) for tissue regeneration represents a potential strategy for the treatment of SCI. However, adult NSPCs largely differentiate into glial cells and contribute to glial scar formation in the injured spinal cord. Using virus-mediated delivery system as a potential therapeutics, we examined the effects of neurogenic factors on SCI in a mouse model. We identified that neurogenic factors promote cell proliferation and activation of NSPCs by activating Notch and Nanog signaling pathways during the acute stage of SCI. These factors promote the generation of various types of neurons (e.g., glutamatergic and cholinergic interneurons) and inhibit the generation of GABAergic interneurons in the injured spinal cord. Importantly, during the chronic stage, the treatment reduces glial scar formation and dramatically improves functional locomotion. Collectively, these findings suggest the neurogenic factors represent promising therapeutic genes for the treatment of SCI and provide molecular insight for transcription factor-mediated functional recovery.
NotePh.D.
NoteIncludes bibliographical references
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/t3-8w2j-kh03
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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