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Therapeutic role of neurogenic transcription factors in spinal cord injury
Descriptive
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Title
Therapeutic role of neurogenic transcription factors in spinal cord injury
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Patel
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Misaal N.
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1993-
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Misaal N. Patel
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author
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Li
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Li Cai
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Advisory Committee
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chair
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Firestein
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Bonnie Firestein
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internal member
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Zhiping Pang
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Advisory Committee
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internal member
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Kwan
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Kelvin Y
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Kelvin Y Kwan
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Advisory Committee
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outside member
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Jiang
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Peng
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Peng Jiang
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Advisory Committee
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Rutgers University
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School of Graduate Studies
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theses
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2019
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2019-10
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2019
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English
Abstract
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Spinal cord injury (SCI) results in neuronal damage and glial scar formation, leading to loss of function and paralysis below the injury site. Although there are assistive devices in the market, there are no therapeutics that promote complete repair and regeneration after SCI. Major hurdles in neural regeneration include a limited level of neurogenesis in the adult spinal cord, an inflammatory microenvironment that inhibits neurogenesis, axon regeneration, neuronal relay formation, and myelination at the injury site. Promoting endogenous neural stem and progenitor cells (NSPCs) for tissue regeneration represents a potential strategy for the treatment of SCI. However, adult NSPCs largely differentiate into glial cells and contribute to glial scar formation in the injured spinal cord. Using virus-mediated delivery system as a potential therapeutics, we examined the effects of neurogenic factors on SCI in a mouse model. We identified that neurogenic factors promote cell proliferation and activation of NSPCs by activating Notch and Nanog signaling pathways during the acute stage of SCI. These factors promote the generation of various types of neurons (e.g., glutamatergic and cholinergic interneurons) and inhibit the generation of GABAergic interneurons in the injured spinal cord. Importantly, during the chronic stage, the treatment reduces glial scar formation and dramatically improves functional locomotion. Collectively, these findings suggest the neurogenic factors represent promising therapeutic genes for the treatment of SCI and provide molecular insight for transcription factor-mediated functional recovery.
Subject
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Topic
Biomedical Engineering
Subject
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Topic
Spinal cord -- Wounds and injuries -- Treatment
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Rutgers University Electronic Theses and Dissertations
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ETD_10184
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1 online resource (x, 100 pages) : illustrations
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Ph.D.
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Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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doi:10.7282/t3-8w2j-kh03
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ETD doctoral
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Rights
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The author owns the copyright to this work.
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Name
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Patel
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Misaal
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Permission or license
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2019-08-26 16:25:00
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Misaal Patel
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Rutgers University. School of Graduate Studies
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Embargo
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2019-10-31
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2021-10-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2021.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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