Staff View
Post-translational modifications on the K2 domain modulate SOX9 transcriptional activity in lung cancer

Descriptive

TitleInfo
Title
Post-translational modifications on the K2 domain modulate SOX9 transcriptional activity in lung cancer
Name (type = personal)
NamePart (type = family)
Patrizii
NamePart (type = given)
Michele
DisplayForm
Michele Patrizii
Role
RoleTerm (authority = RULIB)
author
Name (type = personal)
NamePart (type = family)
Bertino
NamePart (type = given)
Joseph R
DisplayForm
Joseph R Bertino
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
chair
Name (type = personal)
NamePart (type = family)
Hu
NamePart (type = given)
Wenwei
DisplayForm
Wenwei Hu
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
internal member
Name (type = personal)
NamePart (type = family)
Chen
NamePart (type = given)
Suzie
DisplayForm
Suzie Chen
Affiliation
Advisory Committee
Role
RoleTerm (authority = RULIB)
outside member
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
School of Graduate Studies
Role
RoleTerm (authority = RULIB)
school
TypeOfResource
Text
Genre (authority = marcgt)
theses
OriginInfo
DateCreated (encoding = w3cdtf); (keyDate = yes); (qualifier = exact)
2019
DateOther (encoding = w3cdtf); (qualifier = exact); (type = degree)
2019-10
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract (type = abstract)
Lung cancer is the deadliest cancer type, accounting for about 25% of all cancer-related deaths. Despite impressive advancements in the molecular characterization of lung cancer, more than 70% of lung cancer patients are still left with either no known clinically relevant driver mutation or with mutations for which there isn’t a targeted therapeutic option available. Thus, there is a great need to understand the underlying biology of this disease and to discover the molecular pathways driving its onset and progression. SOX9 is a transcription factor involved in several processes during embryonic development, and its role in promoting cancer-related features in lung cancer has been established. Here, we characterized the role of post-translational modifications in mediating SOX9-associated functions in the context of lung cancer, with a particular focus on modifications occurring on the K2 domain. We demonstrated that the K2 domain is able to modulate SOX9 transcriptional ability and that changes in the phosphorylation status of specific residues within K2 affect this mechanism. We were able to show that the K2 domain might represent a region of intrinsic disorder within SOX9, and that post-translational modifications are involved in the maintenance of this disorder, potentially resulting in the modulation of SOX9 ability to interact with binding partners. These results uncover the prominent role of the K2 domain in mediating specific SOX9 functions, thus contributing to dissect the mechanistic details of SOX9 impact on lung cancer onset and progression.
Subject (authority = RUETD)
Topic
Pharmacology, Cellular and Molecular
Subject (authority = LCSH)
Topic
Lungs -- Cancer -- Molecular aspects
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_10111
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (x, 104 pages) : illustrations
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier (type = doi)
doi:10.7282/t3-jgr0-nt90
Genre (authority = ExL-Esploro)
ETD doctoral
Back to the top

Rights

RightsDeclaration (ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Patrizii
GivenName
Michele
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-07-08 09:08:14
AssociatedEntity
Name
Michele Patrizii
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2019-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2021-10-30
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 30th, 2021.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
Back to the top

Technical

RULTechMD (ID = TECHNICAL1)
ContentModel
ETD
OperatingSystem (VERSION = 5.1)
windows xp
CreatingApplication
Version
1.4
ApplicationName
macOS Version 10.14.5 (Build 18F132) Quartz PDFContext
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-07-08T15:32:52
DateCreated (point = end); (encoding = w3cdtf); (qualifier = exact)
2019-07-08T15:32:52
Back to the top
Version 8.5.5
Rutgers University Libraries - Copyright ©2024