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Molecular modeling of nanoparticle interactions with soft complex interfaces
Descriptive
TitleInfo
Title
Molecular modeling of nanoparticle interactions with soft complex interfaces
Name
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Burgess
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Sean Mackenzie
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Sean Mackenzie Burgess
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author
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Chiew
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Yee Chiew
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Advisory Committee
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chair
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Rutgers University
Role
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degree grantor
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School of Graduate Studies
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school
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theses
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2020
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2020-01
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2020
Language
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English
Abstract
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Understanding the interactions between nanoparticles (NP) and soft, complex interfaces, such as lipid bilayers (LB), and high-density polymer grafted substrates, is important for many biological, and technological processes, as well as for assessing health threats related to nanoparticle commercialization. Adhesion, intake, and release of hydrophobic NPs by 1,2-dimyristoyl-sn-glycero-3-phosphocholine bilayers are explored, and the dynamics of unforced transport of NP across the LB is evaluated. NP intake may also cause cell instability that is studied by modeling the dynamics of the tension-induced hole formation in Np-loaded LBs. An NP size dependent relationship is established for the probability of membrane rupture within a given time as a function of the membrane tension. Next, the NP motion in polymer brush (PB) grafted channels is explored focusing on the process on NP chromatographic separation. . The existing theory, which considers NP motion in hard- wall channels with is extended for the case of PB-grafted substrates. Additionally, separation experiments are performed to develop a hybrid liquid chromatography model, which combines the hydrodynamic and size-exclusion chromatography approaches to predict the residence time in polymer-grafted chromatographic columns.
Subject
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Topic
Nanoparticles
Subject
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Topic
Chemical and Biochemical Engineering
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Rutgers University Electronic Theses and Dissertations
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ETD_10528
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Extent
1 online resource (xiv, 146 pages) : illustrations
Note
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Ph.D.
Note
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Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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NjNbRU
Identifier
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doi:10.7282/t3-905f-ec07
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ETD doctoral
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Rights
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The author owns the copyright to this work.
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Name
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Burgess
GivenName
Sean
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Permission or license
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2020-01-13 00:31:14
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Sean Burgess
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Affiliation
Rutgers University. School of Graduate Studies
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2020-01-13T16:53:54
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2020-01-13T16:53:54
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