Description
TitlePhoto-responsive nanomaterials for probing bio- and neuro- interfaces
Date Created2020
Other Date2020-01 (degree)
Extent1 online resource (xi, 297 pages) : illustrations
DescriptionRecent discoveries in both investigating and modulating cells have enriched our understanding and knowledge about cellular behavior, signaling pathways as well as molecular mechanisms. In addition, tremendous advances in nanomaterials, especially nanomaterial-based optical probes, have enabled scientists to not only study various molecular, cellular, cell-environment interactions at the nanoscale level, but also interrogate, perturb as well as manipulate biological behaviors at different scale functionally and therapeutically. As a result, nanotechnology-based optical investigation and manipulation at the biological and neural interfaces have gained great research interests and attentions for the purpose of understanding studying physiological mechanisms, identifying pathogenic pathways, and developing enhanced treatments of devastating diseases.
In the introductory chapter, the discussion is focused on recent advances of nano-optical probe-based cellular sensing and manipulations. Firstly, the nanoprobe-based optical sensing of cellular environments is elaborated, followed by detailed discussion on applications in cellular activities investigation. Finally, light-mediated nanoparticle-based cellular manipulations and behavior controls is discussed.
To better investigate and further regulate the complex biological processes, near infrared (NIR) could be an ideal stimulus for modulating the spatiotemporal dynamics of signals in living cells and organisms with high resolution. Subsequently, initial work on the development of NIR-responsive lanthanide-doped nanomaterials with orthogonal emissions for dynamic photo-switching reaction control is presented. Two studies utilizing NIR-responsive nanomaterials for small molecule release monitoring and neurotransmitter imaging are stated. These works represent the sensing aspects of photo-responsive nanomaterials probing at the cancer and neural interfaces. Two proof-of-concept studies on NIR-mediated stem cell behaviors control is incorporated in the later chapters.
Lastly, in the final chapter, recent works on biodegradable dendritic peptide nanoparticle platform for regenerative medicine and cancer therapeutic applications are discussed. Moreover, the translational journey and perspectives of the dendritic peptide nanoparticle system for next-generation pancreatic cancer therapy are presented.
NotePh.D.
NoteIncludes bibliographical references
Genretheses, ETD doctoral
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.