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Photo-responsive nanomaterials for probing bio- and neuro- interfaces
Descriptive
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Title
Photo-responsive nanomaterials for probing bio- and neuro- interfaces
Name
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Zhang
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Yixiao
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1990-
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Yixiao Zhang
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author
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Lee
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Ki-Bum Lee
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chair
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Richard H
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Richard H Ebright
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internal member
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Garfunkel
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Eric
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Eric Garfunkel
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Advisory Committee
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internal member
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Gervasoni
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James E
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James E Gervasoni
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Advisory Committee
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Rutgers University
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School of Graduate Studies
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theses
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2020
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2020-01
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English
Abstract
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Recent discoveries in both investigating and modulating cells have enriched our understanding and knowledge about cellular behavior, signaling pathways as well as molecular mechanisms. In addition, tremendous advances in nanomaterials, especially nanomaterial-based optical probes, have enabled scientists to not only study various molecular, cellular, cell-environment interactions at the nanoscale level, but also interrogate, perturb as well as manipulate biological behaviors at different scale functionally and therapeutically. As a result, nanotechnology-based optical investigation and manipulation at the biological and neural interfaces have gained great research interests and attentions for the purpose of understanding studying physiological mechanisms, identifying pathogenic pathways, and developing enhanced treatments of devastating diseases.
In the introductory chapter, the discussion is focused on recent advances of nano-optical probe-based cellular sensing and manipulations. Firstly, the nanoprobe-based optical sensing of cellular environments is elaborated, followed by detailed discussion on applications in cellular activities investigation. Finally, light-mediated nanoparticle-based cellular manipulations and behavior controls is discussed.
To better investigate and further regulate the complex biological processes, near infrared (NIR) could be an ideal stimulus for modulating the spatiotemporal dynamics of signals in living cells and organisms with high resolution. Subsequently, initial work on the development of NIR-responsive lanthanide-doped nanomaterials with orthogonal emissions for dynamic photo-switching reaction control is presented. Two studies utilizing NIR-responsive nanomaterials for small molecule release monitoring and neurotransmitter imaging are stated. These works represent the sensing aspects of photo-responsive nanomaterials probing at the cancer and neural interfaces. Two proof-of-concept studies on NIR-mediated stem cell behaviors control is incorporated in the later chapters.
Lastly, in the final chapter, recent works on biodegradable dendritic peptide nanoparticle platform for regenerative medicine and cancer therapeutic applications are discussed. Moreover, the translational journey and perspectives of the dendritic peptide nanoparticle system for next-generation pancreatic cancer therapy are presented.
In the introductory chapter, the discussion is focused on recent advances of nano-optical probe-based cellular sensing and manipulations. Firstly, the nanoprobe-based optical sensing of cellular environments is elaborated, followed by detailed discussion on applications in cellular activities investigation. Finally, light-mediated nanoparticle-based cellular manipulations and behavior controls is discussed.
To better investigate and further regulate the complex biological processes, near infrared (NIR) could be an ideal stimulus for modulating the spatiotemporal dynamics of signals in living cells and organisms with high resolution. Subsequently, initial work on the development of NIR-responsive lanthanide-doped nanomaterials with orthogonal emissions for dynamic photo-switching reaction control is presented. Two studies utilizing NIR-responsive nanomaterials for small molecule release monitoring and neurotransmitter imaging are stated. These works represent the sensing aspects of photo-responsive nanomaterials probing at the cancer and neural interfaces. Two proof-of-concept studies on NIR-mediated stem cell behaviors control is incorporated in the later chapters.
Lastly, in the final chapter, recent works on biodegradable dendritic peptide nanoparticle platform for regenerative medicine and cancer therapeutic applications are discussed. Moreover, the translational journey and perspectives of the dendritic peptide nanoparticle system for next-generation pancreatic cancer therapy are presented.
Subject
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Chemistry and Chemical Biology
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Cancer -- Imaging
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Nanotechnology
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Rutgers University Electronic Theses and Dissertations
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1 online resource (xi, 297 pages) : illustrations
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Ph.D.
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Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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doi:10.7282/t3-wx89-ae44
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ETD doctoral
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Rights
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The author owns the copyright to this work.
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Zhang
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Yixiao
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Permission or license
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2020-01-09 12:03:45
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Yixiao Zhang
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Rutgers University. School of Graduate Studies
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2020-01-31
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2022-01-30
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Access to this PDF has been restricted at the author's request. It will be publicly available after January 30th, 2022.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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