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The development and evaluation of a contractile, hydrogel scaffold for skeletal muscle tissue engineering
Descriptive
TitleInfo
Title
The development and evaluation of a contractile, hydrogel scaffold for skeletal muscle tissue engineering
Name
(type = personal)
NamePart
(type = family)
Khalili
NamePart
(type = given)
Amin
NamePart
(type = date)
1994-
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Amin Khalili
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Freeman
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(type = given)
Joseph W
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Joseph W Freeman
Affiliation
Advisory Committee
Role
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(authority = RULIB)
chair
Name
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(type = family)
Olabisi
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Ronke
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Ronke Olabisi
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Advisory Committee
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(authority = RULIB)
internal member
Name
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NamePart
(type = family)
Labazzo
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(type = given)
Kristen
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Kristen Labazzo
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Advisory Committee
Role
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(authority = RULIB)
outside member
Name
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Rutgers University
Role
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(authority = RULIB)
degree grantor
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School of Graduate Studies
Role
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school
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Text
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theses
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2020
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(type = degree)
2020-05
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2020
Language
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(type = text)
English
Abstract
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Skeletal muscle tissue has the ability to regenerate and return function to the damaged areas following an incident that has resulted in muscle loss or injury. However, in severe injuries with large volumetric deficiencies, body’s natural healing mechanisms fall short and require artificial interventions. There currently exist surgical treatments such as muscle flaps to promote healing and help damaged skeletal muscle tissue to return to their functional state. However, such treatments have significant drawbacks and often lead to a lowered quality life for patients. The field of tissue engineering has demonstrated preliminary advances through the use of three-dimensional scaffolds as a solution to develop a personalized treatment for volumetric muscle loss. Despite such advances in this field, there remains an abundant of hurdles before scaffolds can become widely used in clinical setting. Recently tissue engineers have been successful to design skeletal muscle scaffolds that led to the fusion of myoblasts into myotubes, however, the lack of electrical and mechanical stimuli similar to the native tissue can prevent the formation of functional muscle. The overall goal of this research project is to develop polymeric scaffolds to deliver the necessary stimuli to form functional skeletal muscles. Herein, Poly(ethylene glycol) diacrylate (PEGDA) has been copolymerized with MAETAC to form an electroactive polymer, that can change size or shape as a response to an electric field, has been combined with PEDOT:PSS to develop a skeletal muscle tissue engineering scaffold. To that end, this project has the following aims: 1) Characterize and optimize a positively charged poly(ethylene glycol) diacrylate based hydrogel as an actuating muscle tissue engineering scaffold; 2) Develop and optimize an electroconductive self-actuating multilayer scaffold for skeletal muscle tissue engineering.
Subject
(authority = LCSH)
Topic
Tissue scaffolds
Subject
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Topic
Biomedical Engineering
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TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
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ETD
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ETD_10600
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application/pdf
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text/xml
Extent
1 online resource (viii, 60 pages) : illustrations
Note
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M.S.
Note
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Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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rucore10001600001
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-t0n0-6036
Genre
(authority = ExL-Esploro)
ETD graduate
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Rights
RightsDeclaration
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Khalili
GivenName
Amin
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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2020-03-04 21:04:53
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Name
Amin Khalili
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
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ETD
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windows xp
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1.4
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2020-03-16T05:56:56
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2020-03-16T05:56:56
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