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The role of the group I metabotropic glutamate receptor agonist, CHPG, in oligodendrocyte regeneration and repair following a cuprizone-induced lesion
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Saitta, Kyle S.. The role of the group I metabotropic glutamate receptor agonist, CHPG, in oligodendrocyte regeneration and repair following a cuprizone-induced lesion. Retrieved from https://doi.org/doi:10.7282/t3-fsm6-tz70

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TitleThe role of the group I metabotropic glutamate receptor agonist, CHPG, in oligodendrocyte regeneration and repair following a cuprizone-induced lesion
NameSaitta, Kyle S. (author); Dreyfus, Cheryl F (chair); Chen, Suzie (internal member); Zhou, Renping (internal member); Wu, Long-Jun (internal member); Wood, Teresa L (outside member); Rutgers University; School of Graduate Studies
Date Created2020
Other Date2020-05 (degree)
SubjectBDNF, Toxicology
Extent1 online resource (xiv, 120 pages) : illustrations
DescriptionDemyelinating diseases or demyelination in response to toxic agents can be debilitating to patients and can greatly impair the quality of life. Therefore, new therapeutic targets are needed that enhance the regeneration and repair of oligodendrocytes, the myelin-producing cells. In an effort to identify drugs that delay demyelination and promote remyelination, previous work from our lab has been evaluating effects of metabotropic glutamate receptor (mGluR) agonists. The current work assesses the role of one such agonist, 2-chloro-5-hydroxyphenylglycine (CHPG), in the cuprizone model of demyelination in mice. Peripheral injection of CHPG was found to work within the lesion site to influence myelination.
NotePh.D.
NoteIncludes bibliographical references
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/t3-fsm6-tz70
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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