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Stem cell therapy combined with CRISPR to engineer anti-inflammatory chondrocytes to improve neuroinflammation in rheumatoid arthritis
Descriptive
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Title
Stem cell therapy combined with CRISPR to engineer anti-inflammatory chondrocytes to improve neuroinflammation in rheumatoid arthritis
Name
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Gary
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LaKeshia
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author
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Fried
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Nathan
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Nathan Fried
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chair
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Saidel
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William
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William Saidel
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internal member
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Dunaev
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Jamie
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Jamie Dunaev
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Advisory Committee
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internal member
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Laws
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Kaitlin
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Kaitlin Laws
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Advisory Committee
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outside member
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Rutgers University
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degree grantor
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Camden Graduate School
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theses
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2020
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2020-10
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English
Abstract
Regenerative medicine has the potential to improve several medical issues, such as tissue damage, diminished cell maintenance/repair and failed organ systems. CRISPR technology provides the opportunity to expand stem cell therapy to not only replace lost cells, but also genetically engineer them to treat certain conditions. Rheumatoid arthritis is one disorder where combining both therapies can improve the patient outcome by genetically engineering replacement chondrocytes to constitutively release anti-inflammatory cytokines. This unique strategy presents the opportunity to not only target the pain produced from joint deterioration, but also continuously replace the cartilage to increase the reduced mobility of Rheumatoid Arthritis diagnosed patients.
Subject
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CRISPR (Genetics)
Subject
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Topic
Biology
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Rutgers University Electronic Theses and Dissertations
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ETD
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Camden Graduate School Electronic Theses and Dissertations
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rucore10005600001
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ETD_11158
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doi:10.7282/t3-4pmc-1b91
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1 online resource (vi, 33 pages)
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M.S.
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Includes bibliographical references
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ETD graduate
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Rights
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The author owns the copyright to this work.
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Name
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Gary
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LaKeshia
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Permission or license
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2020-09-17 01:05:42
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LaKeshia Gary
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Affiliation
Rutgers University. Camden Graduate School
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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2020-09-21T17:19:32
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2020-09-21T17:19:32
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