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Development of new methods for ACYL C-O and C-N crosscoupling

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Title
Development of new methods for ACYL C-O and C-N crosscoupling
Name (type = personal)
NamePart (type = family)
Buchspies
NamePart (type = given)
Jonathan
NamePart (type = date)
1985
DisplayForm
Jonathan Buchspies
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RoleTerm (authority = RULIB); (type = text)
author
Name (type = personal)
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Jaekle
NamePart (type = given)
Frieder
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Frieder Jaekle
Affiliation
Advisory Committee
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chair
Name (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB)
degree grantor
Name (type = corporate)
NamePart
Graduate School - Newark
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school
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Text
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theses
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2020
DateOther (type = degree); (qualifier = exact); (encoding = marc)
2020-10
Language
LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract
Amide and ester bonds are ubiquitous in organic synthesis, polymers, and drug discovery;
therefore the development of catalytic amide and ester bond cross-coupling reactions is of broad
interest to selectively functionalize organic molecules. The use of amides and esters as acyl
transfer reagents has been a burgeoning area in organic chemistry and the main challenge
remains the development of new methods to selectively activate amide and ester bonds.
This thesis describes our studies on: (1) the development of novel transition-metal-catalyzed
transformations of amides and esters by X–C(O) (X = NR2, OR) activation; (2) the development
of new amide and ester precursors for cross-coupling reactions; (3) the development of new,
robust catalytic systems for acyl-cross-coupling reactions of amides and esters.
Specifically, this thesis addresses the development of pentafluorophenyl esters as highly
selective acylating reagents for the Suzuki-Miyaura cross-coupling using Pd-phosphine catalysis.
Then, the development of twisted N-acyl-phthalimides and electronically-activated N-acylcarbazoles and N-acyl-indoles by Nlp to Ar delocalization using Pd–NHC catalyst systems for
acyl cross-coupling is described. Finally, the development of cross-coupling of various amides
using well-defined, air- and moisture-stable Ni–NHC complexes is described.
Subject (authority = RUETD)
Topic
Chemistry
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Title
Rutgers University Electronic Theses and Dissertations
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ETD_11041
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application/pdf
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text/xml
Extent
1 online resource (vii, 113 pages)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Genre (authority = ExL-Esploro)
ETD doctoral
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Title
Graduate School - Newark Electronic Theses and Dissertations
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rucore10002600001
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NjNbRU
Identifier (type = doi)
doi:10.7282/t3-9b40-ak26
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The author owns the copyright to this work.
RightsHolder (type = personal)
Name
FamilyName
Buchspies
GivenName
Jonathan
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2020-07-13 16:30:44
AssociatedEntity
Name
Jonathan Buchspies
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Copyright holder
Affiliation
Rutgers University. Graduate School - Newark
AssociatedObject
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License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
RightsEvent
Type
Embargo
DateTime (encoding = w3cdtf); (qualifier = exact); (point = start)
2020-10-31
DateTime (encoding = w3cdtf); (qualifier = exact); (point = end)
2021-10-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after October 31st, 2021.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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