LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract
Amide and ester bonds are ubiquitous in organic synthesis, polymers, and drug discovery;
therefore the development of catalytic amide and ester bond cross-coupling reactions is of broad
interest to selectively functionalize organic molecules. The use of amides and esters as acyl
transfer reagents has been a burgeoning area in organic chemistry and the main challenge
remains the development of new methods to selectively activate amide and ester bonds.
This thesis describes our studies on: (1) the development of novel transition-metal-catalyzed
transformations of amides and esters by X–C(O) (X = NR2, OR) activation; (2) the development
of new amide and ester precursors for cross-coupling reactions; (3) the development of new,
robust catalytic systems for acyl-cross-coupling reactions of amides and esters.
Specifically, this thesis addresses the development of pentafluorophenyl esters as highly
selective acylating reagents for the Suzuki-Miyaura cross-coupling using Pd-phosphine catalysis.
Then, the development of twisted N-acyl-phthalimides and electronically-activated N-acylcarbazoles and N-acyl-indoles by Nlp to Ar delocalization using Pd–NHC catalyst systems for
acyl cross-coupling is described. Finally, the development of cross-coupling of various amides
using well-defined, air- and moisture-stable Ni–NHC complexes is described.
Subject (authority = RUETD)
Topic
Chemistry
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_11041
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (vii, 113 pages)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Genre (authority = ExL-Esploro)
ETD doctoral
RelatedItem (type = host)
TitleInfo
Title
Graduate School - Newark Electronic Theses and Dissertations
Identifier (type = local)
rucore10002600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
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