LanguageTerm (authority = ISO 639-3:2007); (type = text)
English
Abstract
This work was undertaken to evaluate a novel hydroxypropyl methylcellulose excipient used in the manufacture of hydrophilic matrix tablets for oral controlled release. This material was coprocessed with a small amount of silicon dioxide to provide improvements over the standard material and was shown to have better flow, compactability and less triboelectric charging demonstrating an improved performance in a loss-in-weight feeder. As a result, this material is preferred for use in continuous manufacturing via direct compression which would be problematic for the standard grade. Finally, a methodology was developed to calibrate the material properties for a computer simulation of the loss-in-weight feeder using the discrete element method which was shown to have good correlation with the experimental results.
Subject (authority = local)
Topic
Excipient
Subject (authority = RUETD)
Topic
Pharmaceutical Science
RelatedItem (type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier (type = RULIB)
ETD
Identifier
ETD_11215
PhysicalDescription
Form (authority = gmd)
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
1 online resource (xiv, 175 pages)
Note (type = degree)
Ph.D.
Note (type = bibliography)
Includes bibliographical references
Genre (authority = ExL-Esploro)
External ETD doctoral
RelatedItem (type = host)
TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier (type = local)
rucore10001600001
Location
PhysicalLocation (authority = marcorg); (displayLabel = Rutgers, The State University of New Jersey)
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