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Water interaction with raw, intermediate and final pharmaceutical materials
Descriptive
TitleInfo
Title
Water interaction with raw, intermediate and final pharmaceutical materials
Name
(type = personal)
NamePart
(type = family)
Liu
NamePart
(type = given)
Zhanjie
NamePart
(type = date)
1989-
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Zhanjie Liu
Role
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(authority = RULIB)
author
Name
(type = personal)
NamePart
(type = family)
Drazer
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(type = given)
German
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German Drazer
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
chair
Name
(type = personal)
NamePart
(type = family)
Callegari
NamePart
(type = given)
Gerardo
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Gerardo Callegari
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
co-chair
Name
(type = personal)
NamePart
(type = family)
Cuitino
NamePart
(type = given)
Alberto
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Alberto Cuitino
Affiliation
Advisory Committee
Role
RoleTerm
(authority = RULIB)
internal member
Name
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NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
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NamePart
School of Graduate Studies
Role
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school
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Text
Genre
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theses
Genre
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ETD graduate
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2020
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2020-10
Language
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(type = text)
English
Abstract
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Tablets is the most convenient way to take medication and 70% of the total medicines are dispensed in the form of tablets. The effectiveness of such dosage form depends on how the drug dissolves in the fluids of the gastrointestinal tract. The dissolution of tablets is dominated by two factors mainly: Wettability of the blends and disintegration of the tablets. The objective of this study consists of: A) Studying the wettability of pharmaceutical blends by droplet penetration method. B) Understanding of the Swelling of pharmaceutical tablets in contact with water. In droplet penetration section, blends of 90% Lactose, 9% APAP, 1% MgSt with varying shear level (0Rev, 160Rev, 640Rev and 1280Rev) were prepared as porous material. To characterize wettability of blends, the penetration profile of both water and silicone oil, which is the volume of droplet versus time, was plotted. The water penetration process consists of three phase: bouncing phase, waiting phase and penetrating phase. By reviewing the penetration model developed by Denesuk, a new method for dynamic contact angle calculation was developed. The results reveal that the wettability of blends decreases as the increasing of shear level. In tablets swelling section, formulations with varying percentage of Avicel and Lactose (80% Avicel-10% Lactose, 45% Avicel-45% Lactose and 10% Avicel-80% Lactose) were used to make tablets with different compaction force ranging from 4KN to 24KN. A experiment was designed to measure the swelling of tablets and mass of water uptake meantime. Both the swelling profile and the water uptake profile of tablets present two behaviors: linear and non-linear, which reveal two possible liquid uptake mechanisms: capillary penetration and particle swelling. Swelling rate and water uptake rate of tablets can be calculated from the swelling profile and water uptake profile. Both of them are non-monotonic with compaction and formulation.
Subject
(authority = local)
Topic
Pharmaceutical
Subject
(authority = RUETD)
Topic
Chemical and Biochemical Engineering
RelatedItem
(type = host)
TitleInfo
Title
Rutgers University Electronic Theses and Dissertations
Identifier
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ETD
Identifier
ETD_10586
PhysicalDescription
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application/pdf
InternetMediaType
text/xml
Extent
1 online resource (ix, 61 pages) : illustrations
Note
(type = degree)
M.S.
Note
(type = bibliography)
Includes bibliographical references
RelatedItem
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TitleInfo
Title
School of Graduate Studies Electronic Theses and Dissertations
Identifier
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rucore10001600001
Location
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(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-fdfp-7505
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Rights
RightsDeclaration
(ID = rulibRdec0006)
The author owns the copyright to this work.
RightsHolder
(type = personal)
Name
FamilyName
Liu
GivenName
Zhanjie
Role
Copyright Holder
RightsEvent
Type
Permission or license
DateTime
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(qualifier = exact);
(point = start)
2020-02-12 19:45:09
AssociatedEntity
Name
Zhanjie Liu
Role
Copyright holder
Affiliation
Rutgers University. School of Graduate Studies
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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Technical
RULTechMD
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ETD
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windows xp
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1.6
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2020-10-01T10:00:52
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2020-10-01T10:01:06
ApplicationName
Adobe PDF Library 20.12.80
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