TY - JOUR TI - Regulation of organic anion transporters DO - https://doi.org/doi:10.7282/t3-pk7s-n990 PY - 2021 AB - The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters are key players for the translocation of various substances into and out of cells, such as clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins, thus critical for maintaining systemic homeostasis and influencing the pharmacological effects and toxicity of the drugs. Given the crucial roles of OATs in physiological and pathological processes and in determining the therapeutical efficacy and toxicity of many clinical drugs, elucidating the cellular and molecular mechanisms underlying OAT regulation is of great significance. The regulations of OATs can take place at multiple levels, such as at the levels of transcription, post-transcription, translation, and post-translation, and numerous signaling pathways are involved in these regulations. My thesis work focuses on the investigation of post-translational modifications (PTMs) of OATs as well as the related signaling pathways in vitro and in vivo. The first chapter gives a general overview of OATs. Chapters 2-6 describe my investigations on OAT mediated drug-drug interaction (DDI) and the cellular and molecular mechanisms underlying the regulation of OATs by ubiquitination, phosphorylation, and SUMOylation as well as related signaling molecules, such as protein kinases and deubiquitinating enzymes. Lastly, I will discuss about the future direction in chapter 7. KW - Pharmaceutical Science KW - Organic anion transporters LA - English ER -