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Regulation of organic anion transporters
Descriptive
TitleInfo
Title
Regulation of organic anion transporters
Name
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Zhang
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Jinghui
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Jinghui Zhang
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author
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You
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Guofeng
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Guofeng You
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Advisory Committee
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chair
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Hatefi
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Arash
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Arash Hatefi
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Advisory Committee
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internal member
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Michniak-Kohn
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Bozena B
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Bozena B Michniak-Kohn
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Advisory Committee
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internal member
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Chang
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Yoke-Chen
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Yoke-Chen Chang
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Advisory Committee
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outside member
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Rutgers University
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degree grantor
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School of Graduate Studies
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Text
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theses
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ETD doctoral
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2021
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2021-01
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2021
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English
Abstract
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The members of the organic anion transporter (OAT) family are mainly expressed in kidney, liver, placenta, intestine, and brain. These transporters are key players for the translocation of various substances into and out of cells, such as clinical drugs, pesticides, signaling molecules, heavy metal conjugates, components of phytomedicines, and toxins, thus critical for maintaining systemic homeostasis and influencing the pharmacological effects and toxicity of the drugs.
Given the crucial roles of OATs in physiological and pathological processes and in determining the therapeutical efficacy and toxicity of many clinical drugs, elucidating the cellular and molecular mechanisms underlying OAT regulation is of great significance. The regulations of OATs can take place at multiple levels, such as at the levels of transcription, post-transcription, translation, and post-translation, and numerous signaling pathways are involved in these regulations. My thesis work focuses on the investigation of post-translational modifications (PTMs) of OATs as well as the related signaling pathways in vitro and in vivo.
The first chapter gives a general overview of OATs. Chapters 2-6 describe my investigations on OAT mediated drug-drug interaction (DDI) and the cellular and molecular mechanisms underlying the regulation of OATs by ubiquitination, phosphorylation, and SUMOylation as well as related signaling molecules, such as protein kinases and deubiquitinating enzymes. Lastly, I will discuss about the future direction in chapter 7.
Given the crucial roles of OATs in physiological and pathological processes and in determining the therapeutical efficacy and toxicity of many clinical drugs, elucidating the cellular and molecular mechanisms underlying OAT regulation is of great significance. The regulations of OATs can take place at multiple levels, such as at the levels of transcription, post-transcription, translation, and post-translation, and numerous signaling pathways are involved in these regulations. My thesis work focuses on the investigation of post-translational modifications (PTMs) of OATs as well as the related signaling pathways in vitro and in vivo.
The first chapter gives a general overview of OATs. Chapters 2-6 describe my investigations on OAT mediated drug-drug interaction (DDI) and the cellular and molecular mechanisms underlying the regulation of OATs by ubiquitination, phosphorylation, and SUMOylation as well as related signaling molecules, such as protein kinases and deubiquitinating enzymes. Lastly, I will discuss about the future direction in chapter 7.
Subject
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Topic
Pharmaceutical Science
Subject
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Topic
Organic anion transporters
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Rutgers University Electronic Theses and Dissertations
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1 online resource (xiii, 126 pages) : illustrations
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Ph.D.
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Includes bibliographical references
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School of Graduate Studies Electronic Theses and Dissertations
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doi:10.7282/t3-pk7s-n990
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Rights
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The author owns the copyright to this work.
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Name
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Zhang
GivenName
Jinghui
Role
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Permission or license
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2021-01-04 11:05:09
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Jinghui Zhang
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Affiliation
Rutgers University. School of Graduate Studies
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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2021-01-31
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2022-01-31
Detail
Access to this PDF has been restricted at the author's request. It will be publicly available after January 31st, 2022.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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