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Analyses of tRNA and rRNA derived fragments across animal kingdom
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Guan, Lingyu. Analyses of tRNA and rRNA derived fragments across animal kingdom. Retrieved from https://doi.org/doi:10.7282/t3-67sc-en44

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TitleAnalyses of tRNA and rRNA derived fragments across animal kingdom
NameGuan, Lingyu (author); Grigoriev, Andrey (chair); Lee, Kwangwon (internal member); Shende, Sunil (internal member); Bhatt, Shantanu (outside member); Rutgers University; Camden Graduate School
Date Created2021
Other Date2021-05 (degree)
SubjecttRNA-derived fragments, Computational and Integrative Biology
Extent1 online resource (vii, 148 pages)
DescriptionTransfer RNA (tRNA) and ribosomal RNA (rRNA) are known for their textbook functions in the translation machinery. With further advances in the high-throughput sequencing, accumulating evidence has revealed their novel functionality as sources of short RNA fragments which may act as post-transcriptional regulators in various organisms. Such tRNA-derived fragments (tRFs) and rRNA-derived fragments (rRFs) have been shown to be implicated in many biological pathways, e.g., ageing, neuronal disorders and cancers, etc. Using large-scale computational analyses of various types of sequencing data, we characterized tRFs and rRFs in flies, mouse and human. We revealed the loading patterns of age-associated rRFs to different Argonaute proteins and suggested their roles in the ageing process of flies. We inferred the potential biogenesis pathway of human rRFs. By comprehensively analyzing the experimentally crosslinked target RNAs of tRFs and rRFs, we investigated the binding mechanisms of these molecules to their targets in the Argonaute proteins and suggested potential regulatory functions.
NotePh.D.
NoteIncludes bibliographical references
Genretheses, ETD doctoral
Persistent URLhttps://doi.org/doi:10.7282/t3-67sc-en44
LanguageEnglish
CollectionCamden Graduate School Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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