DescriptionMultinational investment in foreign countries has attracted mixed reactions from scholars and policymakers concerning their role and impact on host countries. Proponents of MNCs argue that foreign direct investment (FDI) leads to economic growth, creates technological spillover, increases exports, and creates good jobs, among other benefits. In developing economies, some researchers assert MNCs alleviate poverty through their corporate social responsibilities (CSR). Other scholars, in contrast, argue that MNCs widen the income gap in host countries and engage in human rights violations. The benefits have encouraged developing economies to adopt developmental strategies around MNCs' activities in their economies. However, the important relationship between greenfield investments and development has been less interrogated in the literature. Using Ghana as a case study, this research examines multinational greenfield investment in Ghana between 2003 and 2020. Adopting the ordinary least square analysis (OLS), the study demonstrates that greenfield investment has a statistically significant and positive impact on job creation in Ghana. The study identifies gross domestic product (GDP), labor force participation rate, and gross capital formation as important indicators that influence job creation in Ghana. It concludes with recommendations for policymakers and international partners to strategically attract greenfield investment into Ghana's various regions to enhance economic development through job creation.