Versella, Mark Vincent. An examination of differences in acute nicotine withdrawal symptoms between electronic nicotine delivery system and combustible cigarette use. Retrieved from https://doi.org/doi:10.7282/t3-c84b-jw43
DescriptionAcute nicotine withdrawal symptoms have been identified as a barrier to cessation among combustible cigarette smokers. Despite its clinical relevance, work examining acute withdrawal manifestation in electronic nicotine delivery systems (ENDs) users has been sparse. Of the few investigations that have examined withdrawal from ENDs broadly, findings indicate that its symptom intensity is less than withdrawal from combustible cigarettes. The current study aimed to examine multimodal differences in acute nicotine withdrawal symptoms between ENDs users and combustible cigarette smokers. Users of ENDs (n=24) or combustible cigarettes (n=10) completed assessments of autonomic reactivity when using nicotine ad-libitum, and after 24-hour abstention. Users also self-reported withdrawal intensity during abstention via ecological momentary assessment. ENDs and combustible cigarette users evinced differences in self-reported withdrawal symptom trajectory. ENDs users reported a more rapid decrease in positive affect than combustible cigarette users, and combustible cigarette users displaying trending effects suggesting a more rapid increase in sadness withdrawal symptoms than ENDs users during 24-hour abstention. No differences in autonomic reactivity were observed between groups. Generalization of findings is limited due to the small and unbalanced sample. However, this study suggests that ENDs and combustible cigarette users perceive differences in their withdrawal experiences, which merits continued investigation.