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Development of anisotropic orthopaedic medical devices
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Pfaff, William. Development of anisotropic orthopaedic medical devices. Retrieved from https://doi.org/doi:10.7282/t3-19d2-d042

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TitleDevelopment of anisotropic orthopaedic medical devices
NamePfaff, William (author); Dunn, Michael (chair); Gatt, Charles J (member); Weadock, Kevin (member); Freeman, Joseph W (member); Rutgers University; School of Graduate Studies
Date Created2021
Other Date2021-10 (degree)
SubjectBioengineering, Mechanics, Medicine, Medical instruments and apparatus, Orthopedics, Cartilage, Meniscus (Anatomy), Articular cartilage, Intervertebral disk, Device design, Knee, Lateral meniscus, Medical device, Meniscus, Orthopaedic medicine
Extent1 online resource (xi, 139 pages) : illustrations
DescriptionCartilaginous tissue is vital to the mechanical function of several joints throughout the body. However, its lack of vasculature and low cell population make it vulnerable to trauma and degeneration, often leading to pain, instability, and loss of joint function. Often, this requires surgical intervention leading to resection of damaged tissue, prosthetic implants, and arthroplasty. Tissue engineered devices hold the promise of preserving these joints while enabling long-term regeneration of the damaged tissue. In order to recreate the biomechanical functions of these complex tissues, however, these devices need to be anisotropic in design and mechanics. Our group has had success developing and designing composite devices consisting of an isotropic collagen sponge reinforced with an anisotropic polymer fiber network. This dissertation seeks to advance this technology by: [1] designing and testing the viscoelastic function of a 1st generation articular cartilage scaffold, [2] improving a 2nd generation design for an intervertebral disc scaffold using collagen films, [3] testing potential substrate materials for the MeniscoFix™, [4] translating and designing the lateral version of the MeniscoFix™, a medial meniscus device and [5] manufacturing and testing this device to determine its in situ biomechanical function. The results of these aims help progress the preclinical development of these devices, hopefully leading to clinical trials and eventual commercial availability.
NotePh.D.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-19d2-d042
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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