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Shaping of olfactory glomerular circuit and fear learning by GABA(B) receptor- mediated inhibitory signaling
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Bakir, Alper Kagan. Shaping of olfactory glomerular circuit and fear learning by GABA(B) receptor- mediated inhibitory signaling. Retrieved from https://doi.org/doi:10.7282/t3-jvxb-dt21

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TitleShaping of olfactory glomerular circuit and fear learning by GABA(B) receptor- mediated inhibitory signaling
NameBakir, Alper Kagan (author); McGann, John (chair); McGann, John P (member); Bieszczad, Kasia (member); Barker, David J (member); Rutgers University; School of Graduate Studies
Date Created2022
Other Date2022-01 (degree)
SubjectNeurosciences, Olfactory nerve, GABA -- Receptors, Olfactory bulb, Olfactory system, Glomerular circuit
Extent53 pages : illustrations
DescriptionHistorically, research on association learning has always been focused on the cortical and limbic areas. However, it has been known since the 80’s that sensory systems are capable of playing a role in this type of learning as well. Neural correlates of association learning has been observed in several sensory systems, including olfactory system. In the olfactory bulb, it is possible to observe learning induced, stimulus specific plasticity as early as the olfactory sensory neurons. Although the existence of this phenomenon has been shown throughout the olfactory glomerular circuit, there has not been many conclusive findings about the neural underpinnings of it. One of the candidates that may play an important role in establishing this plasticity is changes in GABAᴃ receptor-mediated inhibitory signaling. To investigate if GABAᴃ receptor plasticity is utilized in inducing odor-specific changes in the olfactory system, this study had two goals; understanding the role of the receptor in normal functioning across the glomerular circuit and examining how it changes after odor-specific fear learning. To reach these goals used calcium imaging on behaviorally trained subjects expressing GCaMP6 in OSN, PG or mitral cells before and after application of CGP35348 (a GABAᴃ antagonist). Blockade of GABAᴃ receptors on the OSN axon terminals increased the odor-evoked response amplitudes in all cell types. In the behavioral control groups this increase was not odor dependent. In the animals that received a CS-US fear training, however, the increase in odor-evoked responses for the CS+ odor was significantly lower than the other odors, regardless of the cell type. Furthermore, the results showed that CGP35348 showed its full effects towards the end of the odor-evoked signal and in the fear conditioned animals this latency was even bigger. Overall, our findings suggest that changes in GABAᴃ receptor mediated inhibitory signaling plays an important role in the forming of association learning in the olfactory system, across all the cells that take part in the glomerular circuit.
NoteM.S.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-jvxb-dt21
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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