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Sound-induced contextual modulation of the representation of oriented visual stimuli in the primary visual cortex of awake behaving mice
Descriptive
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English
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theses
Subject
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Topic
Neuroscience
Subject
(authority = local)
Topic
Visual cortex
Subject
(authority = local)
Topic
Multisensory processing
Subject
(authority = local)
Topic
Audiovisual interactions
Subject
(authority = local)
Topic
Cross-modal integration
Abstract
(type = abstract)
The cerebral cortex is continuously receiving sensory information provided by the five senses. The role of sensory processing is to identify and integrate the sensory information necessary for the selection and execution of behaviors most adapted to the environmental conditions. Most of the time, combining or comparing the signals provided by different sensory modalities leads to optimal processing of the information. The mechanisms responsible for the interactions between at least two different sensory modalities are critical for the production of a relevant behavioral response. However, the cellular and network activities underpinning multimodal integration are poorly understood. For decades, scientist thought that multisensory interactions occur only in ‘higher-order’ cortical regions. Only recently, converging evidence has shown that part of cross-modal cortical integration occurs as early as the primary sensory cortices, such as the existence of direct cortico-cortical projections between the primary auditory cortex (A1) and the primary visual cortex (V1). Despite these findings, the effects of sounds on visually-evoked responses along with the influence of the audiovisual context on visual processing and visual perception remain unclear. Therefore, two-photon calcium imaging was performed in V1 of awake mice passively or actively processing oriented visual stimuli in order to determine the effect of sounds on visual processing. The results demonstrated an association between auditory stimulation and improvements on V1 representation of the orientation and the direction of the visual stimulus. This improvement of the representation of the visual stimulus was associated with a decrease in the limits of angular perception of mice performing an angular perception task. Finally, the results indicated that during active audiovisual processing, the modulation of the representation of the visual stimuli in V1 dynamically adapted to the needs of the behavioral task. Altogether, the results showed that other sensory modalities influence visual processing in V1 and visual perception, and are adaptable to the behavioral goal.
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176 pages : illustrations
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Ph.D
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Includes bibliographical references.
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McClure
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John Patrick
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John Patrick McClure
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Krekelberg
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Bart
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Bart Krekelberg
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Pierre-Olivier
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Pierre-Olivier Polack
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Tibor Koós
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Zaborszky
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Laszlo
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Laszlo Zaborszky
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Margolis
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David
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David Margolis
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Graduate School - Newark
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2020
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2021-01
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2019
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Sound-induced contextual modulation of the representation of oriented visual stimuli in the primary visual cortex of awake behaving mice
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Graduate School - Newark Electronic Theses and Dissertations
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rucore10002600001
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Identifier
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doi:10.7282/t3-zfh2-m240
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The author owns the copyright to this work.
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2022-04-12
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
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Copyright protected
Availability
Status
Open
Reason
Permission or license
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Microsoft: Print To PDF
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