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The effect of surface energy and triboelectric charge on the adhesion propensity of dry pharmaceutical powders
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Albayati, Nubul. The effect of surface energy and triboelectric charge on the adhesion propensity of dry pharmaceutical powders. Retrieved from https://doi.org/doi:10.7282/t3-1dfc-vt43

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TitleThe effect of surface energy and triboelectric charge on the adhesion propensity of dry pharmaceutical powders
NameAlbayati, Nubul (author); Muzzio, Fernando (chair); Muzzio, Fernando J. (member); Michniak, Bozena B. (member); Minko, Tamara (member); Rutgers University; School of Graduate Studies
Date Created2022
Other Date2022-05 (degree)
SubjectPharmaceutical sciences, Powders (Pharmacy)
Extent89 pages : illustrations
DescriptionPowder adherence onto the instrument surface during unit operation, which is called the adhesion or sticking phenomenon, is one of the main concerns in pharmaceutical manufacturing. A significant step to resolve this problem is to quantify the adhesion propensity of pharmaceutical compounds and comprehend the physicochemical factors that affect the sticking propensity. The aim of this study is to identify powder surface characterizations which involves both electrostatic properties and surface energy on the adhesion propensity of two Active Pharmaceutical Ingredients (APIs) and excipients. This includes the investigation of the role of both surface material properties as a probable root cause for powder sticking in industrial processing. The V- blender and LabRam were used as a model to evaluate the adhesion propensity of the materials. Semi-Fine Acetaminophen (APAP) and Caffeine Anhydrous were chosen as API (Active Pharmaceutical Ingredients) compounds in this study due to their popularity to cause this issue. Excipients such as Polyethylene oxide (PEO), and Microcrystalline Cellulose (Avicel 105) has been used to evaluate the adhesion level in this study. Additionally, the analysis of the adhesion propensity of blends of Semi-fine acetaminophen (APAP) with Polyethylene oxide (PEO) or Microcrystalline Cellulose (Avicel 105) are also analyzed here.
Results obtained showed that powder adhesion in LabRam follows the same trend as in the V-blender. The adhesion propensity when arranged in the descending order is; APAP> Caffeine>Avicel 105> PEO. This proves that the small device can really predict what’s happening in the V-blender.
The study found very good correlation between electrostatic charge and the adhesion propensity of the materials. The most goes attach or adhere to surfaces is the one with the highest electrostatic charge. In addition, the results revealed a good relation between the adhesion of APAP, Caffeine, and Polyethylene oxide (PEO) and the specific surface energy in term of specific free energy of adsorption -∆GA^SP. In addition, it has been finding that the adhesion decreases when you match the properties of the excipient with the API.
NoteM.S.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-1dfc-vt43
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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