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Assessing effects of cortical injury on the locus coeruleus
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Pandya, Mansi A.. Assessing effects of cortical injury on the locus coeruleus. Retrieved from https://doi.org/doi:10.7282/t3-frfd-ft46

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TitleAssessing effects of cortical injury on the locus coeruleus
NamePandya, Mansi A. (author); Friedman, Wilma (chair); Tran, Tracy (member); Rutgers University; Graduate School - Newark
Date Created2022
Other Date2022-05 (degree)
SubjectBiology, Locus coeruleus, Noradrenergic, TBI, Brain -- Wounds and injuries
Extent52 pages : illustrations
DescriptionTraumatic Brain Injury (TBI) causes neuronal cell death in local area of impact. However, these injuries may also have degenerative effects retrogradely in the afferent neurons that project to the injured areas, which can have long-term consequences. Examining TBI to the cortex can show which populations of neurons are affected by such injuries. TBI has been known to cause necrotic cell death at the core of the injury, and over time cause secondary neuronal loss. Studies have shown that the innervating afferent neurons that project to the site of injury also experience a local trophic change in their target regions, and this may lead to a retrograde degeneration of these neurons. There are many populations of neurons that have afferent innervation to the cortex. Our lab is looking at two populations of these afferent neuronal populations. The cholinergic neurons of the basal forebrain and the noradrenergic neurons of the Locus coeruleus. The loss of neurons during a TBI have been shown to contribute to development of neurodegenerative diseases later in life. A population of neurons that show degenerative effects in cognitive degenerative disease states are the noradrenergic (NA) neurons of the Locus Coeruleus (LC). Therefore, our lab is investigating if projecting neuronal populations such as the basal forebrain (BF) are affected by the cortical injury. Preliminary studies show that there is ipsilateral BF loss. From these observations about the BF neurons, we wanted to investigate whether this loss would be present in a different population of neurons. In this study we investigated the effects of cortical injury on the noradrenergic neurons of the Locus Coeruleus.
NoteM.S.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-frfd-ft46
LanguageEnglish
CollectionGraduate School - Newark Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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