DescriptionCell migration is a fundamental necessity for normal tissue development, as well as a requirement for the progression of metastatic cancer. This migratory capacity is regulated by numerous signaling pathways, transcription factors and cell-adhesion molecules. However, how these elements coordinate to give rise to cellular migration is not well understood. The follicular epithelium of the Drosophila egg chamber is an established model system to study cell migration. Here, I show the ETS transcription factor Pointed (PNT) is sufficient to arrest cell migration of the stretch follicle cells (StCs), and a subsect of cells known as border cells (BCs). This arrest is suggested to be coordinate through an inhibition of cell-adhesion release via shotgun, the Drosophila homolog of E-cadherin (DE-Cad). For the BCs, PNT expression was found to significantly downregulate slbo, a transcription factor necessary for BC formation. Migration of the BCs is partially rescued via co-expression of YAN, an antagonist of PNT. Finally, I suggest an evolutionary conserved role of PNT mediated regulation of E-Cad in Drosophila nebulosa. Together, I present a role for PNT mediated arrest of migratory cells in developing epithelial cells.