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Hybrid nanomaterials for the treatment of central nervous system inflammation and injuries
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Conley, Brian M.. Hybrid nanomaterials for the treatment of central nervous system inflammation and injuries. Retrieved from https://doi.org/doi:10.7282/t3-5djs-b804

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TitleHybrid nanomaterials for the treatment of central nervous system inflammation and injuries
NameConley, Brian M. (author); Lee, Ki-Bum (chair); Lee, Ki-Bum (member); Fabris, Laura (member); Hall, Gene (member); Han, Inbo (member); Rutgers University; School of Graduate Studies
Date Created2022
Other Date2022-10 (degree)
SubjectChemistry, Bioengineering, Cellular biology, Biomaterials, Drug delivery, Nanotechnology, Tissue engineering
Extent1 online resource (187 pages) : illustrations
DescriptionThe central nervous system (CNS) is notoriously difficult to treat due to its limited regenerative capacity and persistent inflammation after injury. A major hurdle for CNS treatments is to mitigate ongoing inflammation and potentially regenerate lost tissue to ultimately improve functional outcomes. Conventional biomaterials and biopolymers have been widely established for tissue engineering and drug delivery. Nonetheless, nanomaterials, which are designed materials with varying dimensions and chemical composition on the nanoscale, can confer many advantageous properties such as higher drug loading, controlled biodegradation, and non-invasive imaging. Here, this dissertation presents research in which the author and the author’s team develops hybrid nanomaterial platforms for anti-inflammatory drug delivery to the injured spinal cord as well as helps to regenerate the intervertebral disc tissue after degeneration. In the first hybrid nanomaterial approach to treat CNS spinal cord injury, we demonstrate the ability to develop a three-dimensional (3D) biodegradable porous hybrid nanoscaffold with two-dimensional (2D) manganese dioxide nanosheets. We show that the implantation of our nanoscaffold reduces macrophage infiltration, fibrotic scarring, and promotes functional recovery after SCI in rat models. In the second hybrid nanomaterial approach, we develop a nanomaterial-embedded peptide hydrogel which can scavenge reactive oxygen species and stimulate ECM deposition and tissue regeneration in the intervertebral disc after degeneration in rat models. Lastly, in our third approach we also demonstrate the ability to develop in vitro platforms to enhance potential cell therapies and screen cellular behavior for generating neurons from somatic cells using a combinatorial biophysical cue array. Overall, this dissertation demonstrates several strategies which incorporate hybrid nanomaterials to treat central nervous system inflammation and injuries.
NotePh.D.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-5djs-b804
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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