DescriptionHumans are drastically changing the availability and distribution of important elements, such as (N) and phosphorus (P), in the environment. However, we still do not have a comprehensive understanding of how ecosystems will respond to these changes. Ecological Stoichiometry has been put forth as a strong framework to gain a mechanistic understanding of how ecological systems may respond to elemental imbalances generated by heterogeneous changes in nutrient availability. However, these responses can be context dependent on local ecological factors, such as local biotic species compositions, and physical conditions (e.g., the identity of the local limiting nutrient). Further, individuals within a particular species may be stoichiometrically plastic, which may shape the severity of their responses to biogeochemical changes. My research attempts to address the gaps in our understanding of the mechanisms of organismal stoichiometry and their complex responses to nutrient enrichment using an integrated approach that includes data synthesis via data integration and meta-analysis, and a field experiment. Using a global database of animal elemental stoichiometry, I tested whether vertebrate and invertebrate body size affects their elemental content, and thus stoichiometric demands. I also conducted two meta-analyses to test the effects of nutrient enrichment on invertebrate community structure. Finally, I evaluated the impacts of nutrient enrichment on aquatic invertebrate communities using a natural microcosm experiment in tank bromeliads. With these approaches, I expected to understand what stoichiometric principles apply broadly across systems and taxonomic groups, and in what circumstances we observe specific responses. This project seeks to expand our current understanding of organismal stoichiometry, in order to gain better insights into the effects of anthropogenic nutrient enrichment on ecological systems.