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Understanding the aggregation mechanism of ligand coated gold nanoparticles in lipid bilayers
Descriptive
TitleInfo
Title
Understanding the aggregation mechanism of ligand coated gold nanoparticles in lipid bilayers
Name
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Ennis
NamePart
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Jahmal
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Jahmal Ennis
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author
Name
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NamePart
(type = family)
Griepenburg
NamePart
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Julie
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Julie Griepenburg
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Advisory Committee
Role
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chair
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NamePart
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O'Malley
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Sean
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Sean O'Malley
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Advisory Committee
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member
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Klein
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Eric
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Eric Klein
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Advisory Committee
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member
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Rutgers University
Role
RoleTerm
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degree grantor
Name
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NamePart
Graduate School - Camden
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school
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Text
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theses
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2023
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2023-01
Language
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English
Abstract
(type = abstract)
Gold nanoparticle aggregation is a phenomenon observed across many disciplines. We are particularly interested in the controlled aggregation of gold nanoparticles in lipid bilayers. While there has been much work done to understand the mechanism of penetration of gold nanoparticles and interactions of charged gold nanoparticle surface ligands with membranes, the mechanism of gold nanoparticle aggregation is not fully understood. A better understanding of the mechanism of gold nanoparticle aggregation can improve many fields including, but not limited to, targeted drug delivery. We use Coarse Grained Molecular Dynamics to study the mechanism of gold nanoparticle aggregation in various membrane compositions. Our results suggest that both membrane deformation and microscopic lipid deformation lead to aggregation, while ligand chain entropy acts as a balance to reduce aggregation and structure gold nanoparticle’s.
Subject
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Topic
Biophysics
Subject
(authority = RUETD)
Topic
Nanotechnology
Subject
(authority = RUETD)
Topic
Computer science
Subject
(authority = local)
Topic
Aggregation
Subject
(authority = local)
Topic
Gold nanoaprticles
Subject
(authority = local)
Topic
Ligands
Subject
(authority = local)
Topic
Lipid membrane
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Title
Rutgers University Electronic Theses and Dissertations
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http://dissertations.umi.com/graduateschool.camden.rutgers:10067
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Note
Supplementary File: GNPagg.pdf
Extent
26 pages : illustrations
Note
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M.S.
Note
(type = bibliography)
Includes bibliographical references
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TitleInfo
Title
Camden Graduate School Electronic Theses and Dissertations
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rucore10005600001
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NjNbRU
Identifier
(type = doi)
doi:10.7282/t3-3w4n-k034
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Rights
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The author owns the copyright to this work.
RightsHolder
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Name
FamilyName
Ennis
GivenName
Jahmal
Role
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RightsEvent
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Permission or license
DateTime
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2023-02-23T10:43:25
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Name
Jahmal Ennis
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - Camden
AssociatedObject
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Copyright
Status
Copyright protected
Availability
Status
Open
Reason
Permission or license
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