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The role of lateral hypothalamus corticotropin releasing factor-expressing neurons in the effects of chronic stress on feeding behaviors
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Bazer, Allyson. The role of lateral hypothalamus corticotropin releasing factor-expressing neurons in the effects of chronic stress on feeding behaviors. Retrieved from https://doi.org/doi:10.7282/t3-jv6x-rx36

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TitleThe role of lateral hypothalamus corticotropin releasing factor-expressing neurons in the effects of chronic stress on feeding behaviors
NameBazer, Allyson (author); Samuels, Benjamin (chair); Barker, David (member); Shors, Tracey (member); Rutgers University; School of Graduate Studies
Date Created2023
Other Date2023-01 (degree)
SubjectPsychology, Corticotropin releasing hormone
Extent33 pages
DescriptionThe lateral hypothalamus (LH), which regulates feeding, stress, reward, and motivation behavior, is a heterogeneous structure with distinct cell populations defined by expression of specific neural markers. One such population are corticotropin releasing factor (CRF) neurons, which are implicated in chronic stress. However, LH CRF neurons are poorly characterized and their impact on feeding behavior and motivation is unknown. This study aimed to characterize CRF neurons in the LH by comparing co-expression of VGat and VGlut2 mRNA through in situ hybridization (RNAscope). We also aimed to assess the function of CRF neurons using chemogenetics. CRF-ires-cre mice injected with either Gq-DREADD, Gi-DREADD, or control were run through free access feeding and effort-related choice to gauge appetite and motivated behavior. CRF neurons in the LH were found to be primarily GABAergic. Activation of LH CRF neurons via Gq-DREADD increased motivated behavior and locomotion but did not have an impact on feeding behavior.
NoteM.S.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-jv6x-rx36
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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