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Cerebrospinal fluid modulation for enhanced drug delivery in the brain
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Wood, Caroline Michelle. Cerebrospinal fluid modulation for enhanced drug delivery in the brain. Retrieved from https://doi.org/doi:10.7282/t3-vg2x-ny66

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TitleCerebrospinal fluid modulation for enhanced drug delivery in the brain
NameWood, Caroline Michelle (author); Sy, Jay (chair); Alder, Janet (member); Roth, Charles (member); Cai, Li (member); Rutgers University; School of Graduate Studies
Date Created2023
Other Date2023-01 (degree)
SubjectBiomedical engineering, Cerebrospinal fluid
Extent153 pages : illustrations
DescriptionDeveloping safe and efficacious treatments for central nervous system disorders is difficult as the brain’s physiology limits drug penetration and distribution while promoting efflux. In addition, many complex transport mechanisms within the central nervous system are not fully understood. This dissertation investigates a novel approach to improve the pharmacokinetic profiles of drugs in the central nervous system by modulating cerebrospinal fluid flow and altering drug clearance rates. This was accomplished by 1) developing fabrication methods and characterizing polymeric drug delivery systems capable of co-delivering small molecule modulators of cerebrospinal fluid production and 2) creating a pharmacokinetic model to elucidate cerebrospinal fluid flow rates and sustained drug release rates necessary to improve treatment pharmacokinetics. Within this work, we also explored parameters for developing primary cell based in vitro systems of choroid plexus tissue, an epithelial monolayer responsible for cerebrospinal fluid secretion. These results demonstrate the feasibility of fabricating localized drug delivery systems to deliver cerebrospinal fluid modulating-drugs and provide quantitative predictions of the improvements these systems have on co-delivered drug pharmacokinetics in the brain. The drug delivery, computational, and cellular tools produced within this work also provide the scientific community improved methods to develop novel treatment strategies for neurological conditions directly impacted by choroid plexus function and cerebrospinal fluid flow.
NotePh.D.
NoteIncludes bibliographical references
Genretheses
Persistent URLhttps://doi.org/doi:10.7282/t3-vg2x-ny66
LanguageEnglish
CollectionSchool of Graduate Studies Electronic Theses and Dissertations
Organization NameRutgers, The State University of New Jersey
RightsThe author owns the copyright to this work.
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