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Genetic variation and population structure in wild isolates of Caenorhabditis elegans collected from California
Descriptive
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Title
Genetic variation and population structure in wild isolates of Caenorhabditis elegans collected from California
Name
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Dey
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Alivia
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Alivia Dey
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author
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Chiu
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Dr. Chi-hua
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Advisory Committee
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Dr. Chi-hua Chiu
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chair
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Hey
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Dr. Jody
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Advisory Committee
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Dr. Jody Hey
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internal member
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Singson
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Dr. Andrew
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Advisory Committee
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Dr. Andrew Singson
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
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theses
OriginInfo
DateCreated
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2007
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2007
Language
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English
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electronic
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application/pdf
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text/xml
Extent
vii, 41 pages
Abstract
Though much widespread in distribution, the nematode worm Caenorhabditis elegans exhibits low levels of genetic variation at the DNA sequence level, a paradox which may be partly explained by its typical self-fertilization mode of reproduction. However recent work on the genetic structure of natural populations of C. elegans from France, Scotland and Portugal suggests a substantial level of outcrossing together with finding of a very strong local population structure. To find out whether this same occurrence extrapolates to other wild isolates of worm populations, the present study was carried on worm populations from California. Here, genetic variation is studied by detecting single nucleotide polymorphisms in a random genome-wide manner using Amplified Fragment Length Polymorphism analysis (AFLP). The worms used in this study are natural isolates of C. elegans collected from parks and gardens around the Los Angeles area in southern California. Some populations sampled were a few meters apart, enabling the assessment of variation and population structure on a very local scale. As previous studies, a low overall genetic diversity was found with these worm populations. The finding of a strong population structure and high linkage disequilibrium both within and between chromosomes was also concurrent with the findings from other wild isolates. All these findings elucidate the extra-ordinary evolutionary dynamics of these sets of worm from the wild.
Note
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M.S.
Note
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Includes bibliographical references (p. 38-41).
Subject
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Topic
Microbiology and Molecular Genetics
Subject
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Topic
Caenorhabditis elegans
Subject
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Topic
Variation (Biology)
Subject
(ID = SUBJ4);
(authority = ETD-LCSH)
Topic
Worms--Genetics
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.15814
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ETD_348
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NjNbRU
Identifier
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doi:10.7282/T39C6XWS
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
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Copyright protected
Availability
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Open
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Name
Alivia Dey
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Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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Technical
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