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Acidity and proton affinity measurement of cytosine by multiple methods in the gas phase

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TypeOfResource
Text
TitleInfo (ID = T-1); (type = uniform)
Title
Acidity and proton affinity measurement of cytosine by multiple methods in the gas phase
Identifier (type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.16617
Identifier
ETD_456
Language
LanguageTerm (authority = ISO639-2)
eng
Genre (authority = marcgt)
theses
Subject (ID = SBJ-1); (authority = RUETD)
Topic
Chemistry and Chemical Biology
Subject (ID = SBJ-1); (authority = ETD-LCSH)
Topic
DNA--Analysis
Subject (ID = SBJ-1); (authority = ETD-LCSH)
Topic
Nucleic acids
Abstract
The measurement of the intrinsic acidity of nucleic bases is essential for understanding the fundamental properties in biological systems. The Hydrogen bonding is critical to DNA stability and reactivity of oligonucleotides. The strength of hydrogen bonding can be gauged by the intrinsic acidity of the donor NH groups and the intrinsic basicity of acceptor atoms. Acidity is also indicative of the leaving group ability of a nucleobase in deglycosylation processes.
In this dissertation, we examine the gas phase acidity and proton affinity of cytosine using Fourior transform mass spectrometry (FTMS), liquid chromatography mass spectrometry (LCMS) and ab initio calculations at B3LYP/6-31+G*. The experimental gas phase acidities and proton affinities were established using bracketing method, equilibrium method and Cooks kinetic method. Finally, we discuss the tautomer problem and deuterated experiments and the possible mechanism of the base excision repair by TDG enzyme.
PhysicalDescription
Extent
vii, 28 pages
InternetMediaType
application/pdf
InternetMediaType
text/xml
Note
Supplementary File: Supporting Information
Note (type = degree)
M.S.
Note (type = bibliography)
Includes bibliographical references (p. 27-28).
Name (ID = NAME-1); (type = personal)
NamePart (type = family)
Li
NamePart (type = given)
Tingting
NamePart (type = date)
1981-
Role
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author
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Tingting Li
Name (ID = NAME-2); (type = personal)
NamePart (type = family)
Lee
NamePart (type = given)
Jeehiun
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chair
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Advisory Committee
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Jeehiun Lee
Name (ID = NAME-3); (type = personal)
NamePart (type = family)
Romsted
NamePart (type = given)
Larry
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internal member
Affiliation
Advisory Committee
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Larry Romsted
Name (ID = NAME-4); (type = personal)
NamePart (type = family)
Talaga
NamePart (type = given)
David
Role
RoleTerm (authority = RULIB); (type = )
internal member
Affiliation
Advisory Committee
DisplayForm
David Talaga
Name (ID = NAME-1); (type = corporate)
NamePart
Rutgers University
Role
RoleTerm (authority = RULIB); (type = )
degree grantor
Name (ID = NAME-2); (type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm (authority = RULIB); (type = )
school
OriginInfo
DateCreated (point = ); (qualifier = exact)
2007
DateOther (qualifier = exact); (type = degree)
2007
Location
PhysicalLocation (authority = marcorg)
NjNbRU
RelatedItem (type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier (type = local)
rucore19991600001
Identifier (type = doi)
doi:10.7282/T3DR2VXM
Genre (authority = ExL-Esploro)
ETD graduate
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The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
AssociatedEntity (AUTHORITY = rulib); (ID = 1)
Name
Tingting Li
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
RightsEvent (AUTHORITY = rulib); (ID = 1)
Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject (AUTHORITY = rulib); (ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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