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Effects of temporary inactivation of dorsal hippocampus on explicitly nonspatial, unimodal, contextual fear learning
Descriptive
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Title
Effects of temporary inactivation of dorsal hippocampus on explicitly nonspatial, unimodal, contextual fear learning
Name
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Parsons
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Teresa Camille
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Teresa Camille Parsons
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author
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Otto
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Timothy
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Advisory Committee
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Timothy Otto
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chair
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Rovee-Collier
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Carolyn
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Advisory Committee
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Carolyn Rovee-Collier
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internal member
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West
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Mark
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Advisory Committee
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Mark West
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Rutgers University
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degree grantor
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Graduate School - New Brunswick
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school
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theses
OriginInfo
DateCreated
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2008
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2008-01
Language
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English
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electronic
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Extent
iii, 36 pages
Abstract
Several studies have reported that dorsal hippocampal damage attenuates the acquisition (Kim et al., 1993; Phillips & LeDoux, 1992; Young et al., 1994) or expression (Anagnostaras et al., 1999; Holt & Maren, 1999) of recently acquired contextual fear conditioning. "Context" is often operationalized as the conditioning chamber in which CS-US pairings occurred. However, the hippocampus is known to participate in spatial learning, presenting interpretative difficulties regarding the role of dorsal hippocampus in learning and memory. The current study examined the effects of temporary inactivation of DH on freezing, rearing, ambulating, grooming, and whisking behavior in an explicitly nonspatial contextual fear conditioning paradigm, where olfactory stimuli served as temporally and spatially diffuse contexts. Results indicate that temporary inactivation of DH produced both anterograde and retrograde deficits in contextually conditioned freezing, while sparing the acquisition and expression of freezing to a discrete auditory CS. Further, animals with DH inactivation froze modestly and similarly to the unsafe and safe contextual stimuli, while intact animals froze robustly to the unsafe, but not the safe, contextual stimulus. These data indicate that there is a decidedly nonspatial component to the role of DH in contextual conditioning, and suggest that olfactory contextual conditioning is a fruitful means of further exploring this function.
Note
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M.S.
Note
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Includes bibliographical references (p. 32-36).
Subject
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Topic
Psychology
Subject
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Topic
Fear
Subject
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Topic
Emotional conditioning
Subject
(ID = SUBJ4);
(authority = ETD-LCSH)
Topic
Hippocampus (Brain)
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Graduate School - New Brunswick Electronic Theses and Dissertations
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rucore19991600001
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http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17209
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ETD_649
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NjNbRU
Identifier
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doi:10.7282/T3WH2QCQ
Genre
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ETD graduate
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Rights
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The author owns the copyright to this work.
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Copyright protected
Availability
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Open
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Name
Teresa Parsons
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Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
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Non-exclusive ETD license
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Author Agreement License
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I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
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