RUcore: Rutgers University Community Repository
Pharmacogenomic and mechanistic studies on dietary factors in chemoprevention of cancer
Descriptive
TitleInfo
(displayLabel = Citation Title);
(type = uniform)
Title
Pharmacogenomic and mechanistic studies on dietary factors in chemoprevention of cancer
Name
(ID = NAME001);
(type = personal)
NamePart
(type = family)
Nair
NamePart
(type = given)
Sujit Sukumar
DisplayForm
Sujit Sukumar Nair
Role
RoleTerm
(authority = RUETD)
author
Name
(ID = NAME002);
(type = personal)
NamePart
(type = family)
Kong
NamePart
(type = given)
Ah-Ng Tony
Affiliation
Advisory Committee
DisplayForm
Ah-Ng Tony Kong
Role
RoleTerm
(authority = RULIB)
chair
Name
(ID = NAME003);
(type = personal)
NamePart
(type = family)
Minko
NamePart
(type = given)
Tamara
Affiliation
Advisory Committee
DisplayForm
Tamara Minko
Role
RoleTerm
(authority = RULIB)
internal member
Name
(ID = NAME004);
(type = personal)
NamePart
(type = family)
You
NamePart
(type = given)
Guofeng
Affiliation
Advisory Committee
DisplayForm
Guofeng You
Role
RoleTerm
(authority = RULIB)
internal member
Name
(ID = NAME005);
(type = personal)
NamePart
(type = family)
Cai
NamePart
(type = given)
Li
Affiliation
Advisory Committee
DisplayForm
Li Cai
Role
RoleTerm
(authority = RULIB)
outside member
Name
(ID = NAME006);
(type = corporate)
NamePart
Rutgers University
Role
RoleTerm
(authority = RULIB)
degree grantor
Name
(ID = NAME007);
(type = corporate)
NamePart
Graduate School - New Brunswick
Role
RoleTerm
(authority = RULIB)
school
TypeOfResource
Text
Genre
(authority = marcgt)
theses
OriginInfo
DateCreated
(qualifier = exact)
2008
DateOther
(qualifier = exact);
(type = degree)
2008-05
Language
LanguageTerm
English
PhysicalDescription
Form
(authority = marcform)
electronic
InternetMediaType
application/pdf
InternetMediaType
text/xml
Extent
xxxi, 334 pages
Abstract
Pharmacogenomic profiling of cancer has recently seen much activity with the accessibility of the newest generation of high-throughput platforms and technologies. A myriad of mechanistic studies have been devoted to identifying dietary factors that can help prevent cancer, with evidence gleaned from epidemiologic studies revealing an inverse correlation between the intake of cruciferous vegetables and the risk of certain types of cancer. To develop a comprehensive understanding of cancer pathogenesis, and potential for chemopreventive intervention with dietary factors, an integrated approach that encompasses both pharmacogenomic and mechanistic aspects is desirable. Our transcriptomic profiling of butylated hydroxyanisole-induced Nuclear Factor-E2-related factor 2 (Nrf2)-dependent genes in Nrf2-deficient mice identified several germane molecular targets for prevention. Toxicogenomic analyses of endoplasmic reticulum stress inducer tunicamycin in Nrf2-deficient mice elucidated Nrf2-regulated unfolded protein response effects. Mechanistic studies on a combination of sulforaphane and (-) epigallocatechin-3-gallate in HT-29 AP-1 (Activator Protein-1) cells revealed a synergy in colon cancer chemoprevention. Pharmacogenomic studies of this combination in PC-3 AP-1 cells provided a discursive framework for understanding putative crosstalk between Nrf2 and AP-1 in prostate cancer chemoprevention. Regulatory potential for concerted modulation of Nrf2 and Nuclear Factor-κB (Nfκb1) in inflammation and carcinogenesis was delineated by bioinformatic analyses. Metabolomic approaches identified potential prognostic biomarkers in human prostate cancer. Differential biological networks in prostate cancer were elicited in androgen-dependent 22Rv1 cells, androgen- and estrogen-dependent LNCaP cells and androgen-independent DU 145 and PC-3 cells. Taken together, our identification of Nrf2-regulated molecular targets by expression profiling using dietary factors, synergistic effects in combinatorial use of dietary factors in colon cancer, regulatory studies on crosstalk between Nrf2 and AP-1 in prostate cancer, bioinformatic analyses of concerted modulation of Nrf2 and Nfkb1 in inflammation and carcinogenesis, metabolomic identification of biomarkers, and delineation of target hubs in differential prostate cancer biological networks, greatly enhance our understanding of the transcriptional circuitry in cancer and important master regulatory nodes including Nrf2 that might potentially be exploited for chemopreventive intervention with dietary factors.
Note
(type = degree)
Ph.D.
Note
(type = bibliography)
Includes bibliographical references (p. 311-331).
Subject
(ID = SUBJ1);
(authority = RUETD)
Topic
Pharmaceutical Science
Subject
(ID = SUBJ2);
(authority = ETD-LCSH)
Topic
Cancer--Diet therapy
Subject
(ID = SUBJ3);
(authority = ETD-LCSH)
Topic
Cancer--Chemoprevention
RelatedItem
(type = host)
TitleInfo
Title
Graduate School - New Brunswick Electronic Theses and Dissertations
Identifier
(type = local)
rucore19991600001
Identifier
(type = hdl)
http://hdl.rutgers.edu/1782.2/rucore10001600001.ETD.17367
Identifier
ETD_981
Location
PhysicalLocation
(authority = marcorg);
(displayLabel = Rutgers, The State University of New Jersey)
NjNbRU
Identifier
(type = doi)
doi:10.7282/T3K937VQ
Genre
(authority = ExL-Esploro)
ETD doctoral
Back to the top
Rights
RightsDeclaration
(AUTHORITY = GS);
(ID = rulibRdec0006)
The author owns the copyright to this work.
Copyright
Status
Copyright protected
Availability
Status
Open
AssociatedEntity
(AUTHORITY = rulib);
(ID = 1)
Name
Sujit Nair
Role
Copyright holder
Affiliation
Rutgers University. Graduate School - New Brunswick
RightsEvent
(AUTHORITY = rulib);
(ID = 1)
Type
Permission or license
Detail
Non-exclusive ETD license
AssociatedObject
(AUTHORITY = rulib);
(ID = 1)
Type
License
Name
Author Agreement License
Detail
I hereby grant to the Rutgers University Libraries and to my school the non-exclusive right to archive, reproduce and distribute my thesis or dissertation, in whole or in part, and/or my abstract, in whole or in part, in and from an electronic format, subject to the release date subsequently stipulated in this submittal form and approved by my school. I represent and stipulate that the thesis or dissertation and its abstract are my original work, that they do not infringe or violate any rights of others, and that I make these grants as the sole owner of the rights to my thesis or dissertation and its abstract. I represent that I have obtained written permissions, when necessary, from the owner(s) of each third party copyrighted matter to be included in my thesis or dissertation and will supply copies of such upon request by my school. I acknowledge that RU ETD and my school will not distribute my thesis or dissertation or its abstract if, in their reasonable judgment, they believe all such rights have not been secured. I acknowledge that I retain ownership rights to the copyright of my work. I also retain the right to use all or part of this thesis or dissertation in future works, such as articles or books.
Back to the top
Technical
Format
(TYPE = mime);
(VERSION = )
application/x-tar
FileSize
(UNIT = bytes)
7269888
Checksum
(METHOD = SHA1)
86c429fed5efaa9018ff7c4e6d79088e6b357f48
ContentModel
ETD
CompressionScheme
other
OperatingSystem
(VERSION = 5.1)
windows xp
Format
(TYPE = mime);
(VERSION = NULL)
application/x-tar
Back to the top
Statistical Profile